The Los Angeles Chargers (8-6) meet the Indianapolis Colts (4-9-1) in Week 16 of the 2022 regular season.
Here are the betting odds for the matchup, per Tipico Sportsbook:
| Spread | Moneyline | Total Points | |
| Los Angeles Chargers | -4.5 | -210 | O 46 -107 |
| Indianapolis Colts | +4.5 | +180 | U 46 -113 |
The Chargers are coming off a 17-14 victory over the Titans.
The defense made life difficult for Ryan Tannehill, sacking him four times. Justin Herbert led a game-winning drive with just 48 seconds remaining in the fourth quarter, going 52 yards on five plays to set up the 43-yard field goal by Cameron Dicker.
Meanwhile, the Colts were the victim of the largest comeback in NFL history, as the Vikings erased a 33-point halftime deficit to complete a 39-36 overtime victory. Matt Ryan became the only starting quarterback on two 25-point blown leads.
The last time the Chargers and Colts met was in 2019. Los Angeles won, 30-24.
Monday’s contest will begin at 5:15 pm PT and be televised on ESPN.