The Los Angeles Chargers (5-3) are on the road again in Week 10, this time facing the San Francisco 49ers (4-4) in the Sunday night prime-time game. Kickoff is 8:20 p.m. ET at Levi’s Stadium in Santa Clara (NBC). Below, we look at Chargers vs. 49ers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.
The Chargers are coming off a 20-17 road win over the Atlanta Falcons, covering the 2-point spread. It took a last-second, 37-yard field goal from Cameron Dicker as time expired to give them the win.
Also see: All Week 10 odds and lines
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Chargers at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 1:55 p.m. ET.
- Moneyline (ML): Chargers +245 (bet $100 to win $245) | 49ers -320 (bet $320 to win $100)
- Against the spread (ATS): Chargers +7 (-115) | 49ers -7 (-105)
- Over/Under (O/U): 46.5 (O: -110 | U: -110)
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2022 betting stats
- ML: Chargers 5-3 | 49ers 4-4
- ATS: Chargers 5-3 | 49ers 4-4
- O/U: Chargers 4-4 | 49ers 3-5
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Chargers vs. 49ers head-to-head
The 49ers and Chargers have faced one another 15 times including once in the Super Bowl, dating back to 1972.
The Chargers hold an 8-7 all-time advantage and have won the last 5 meetings, 2 of them in overtime.
The 49ers have not beaten the Chargers since the year 2000.
Neither of the starting quarterbacks has faced the other team before.
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