The Buffalo Bills will play the Denver Broncos at home at Highmark Stadium in the Wild Card round.
The Bills (13-4) won 10 of 11 games before their Week 18 loss to the New England Patriots, while the Broncos (10-7) are winners in five of their last seven.
The Bills are favored by 8.5 points and they are playing at home where they were undefeated this season (8-0). Even though the Bills are favored by multiple scores, nothing is guaranteed in the NFL, especially against playoff teams.
There are always a few things that make winning difficult each week. The Bills will need to be wary of them.
Here are three causes for concern for the Bills against the Broncos:
QB Bo Nix’s escapability

What rookie quarterback Bo Nix lacks in experience he makes up for with his creativity and mobility. Nix had the eighth-most rushing yards from a QB in the 2024 regular season (430 yards).
His off-script ability is what has taken the Broncos offense to the next level. The Bills defensive line will need to be disruptive and take away his ability to get outside the pocket or he could start making plays and give the away squad bits of momentum.
Although he’s a rookie, he hasn’t played much like a rookie this year. If the Bills want to take control of the game, they’ll need to mix things up and confuse the young signal caller. Otherwise, he can hurt you.
NFL’s best pass rush

The Broncos lead the league in sacks (63), quarterback pressures (265), and finished third in pressure rate (37.4%). They have been the most productive pass-rushing unit in the NFL by a pretty good margin.
The good thing for the Bills is that they allowed the least sacks in the NFL this year (14). That is the least amount of sacks taken in a season since the 2009 Indianapolis Colts who ended up Super Bowl Champions that year.
This will be a matchup of strength-on-strength in the trenches when the Bills are on offense. If the Bills do what they have all year, and Josh Allen provides his normal dose of off-script magic, then they shouldn’t have a problem. If they slip up, Denver can get home in a hurry.
Patrick Surtain II

Patrick Surtain II may be the best cornerback in the NFL. He was rewarded for his stellar play on Friday with a First-Team All-Pro selection.
Surtain II received the highest coverage grade of all cornerbacks from Pro Football Focus in 2024 (87.4) among those who played 100 snaps.
If there’s one downfall to the Bills offense this year, it’s that they haven’t had a wide receiver consistently beat coverage on the outside. That part of the field will probably be taken away even more than usual with Surtain II out wide.
It will be interesting to see how the Bills approach the passing game, given that Surtain II is capable of shutting down his quarter of the field.
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