St. Louis Cardinals at Arizona Diamondbacks odds, picks and predictions

Analyzing Wednesday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with expert MLB picks, predictions and best bets.

The St. Louis Cardinals (45-57) and the Arizona Diamondbacks (55-47) e wrap up a 3-game series Wednesday at Chase Field in Phoenix. First pitch is scheduled for 3:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Cardinals vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 3-2 after Tuesday’s 3-1 victory

The Cardinals lost for the 4th time in the last 5 games, splashing a bit of cold water on the team’s momentum after a 6-game winning streak from July 15-20. St. Louis managed just a single run Tuesday, the lowest offensive output for the Cards since getting blanked 14-0 on June 29 against the Houston Astros.

The Diamondbacks snapped a 5-game losing streak with Tuesday’s 3-1 win  behind RHP Merrill Kelly. The single run allowed by Arizona pitching was the lowest conceded since July 1 on the road against the Los Angeles Angels.

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Cardinals at Diamondbacks projected starters

RHP Jack Flaherty vs. RHP Zac Gallen

Flaherty (7-6, 4.39 ERA) makes his 20th start. He has a 1.53 WHIP, 4.5 BB/9 and 8.8 K/9 in 104 2/3 innings.

  • Last start: Loss, 6 IP, 4 ER, 8 H (2 HR), 1 BB, 6 K in a 4-3 road loss vs. the Chicago Cubs Friday
  • 2023 road splits: 3-3, 3.55 ERA (63 1/3 IP, 25 ER – 6 HR), .289 opponent batting average (OBA) in 11 starts
  • 2023 vs. Arizona: Loss, 6 IP, 4 ER, 4 H (1 HR), 3 BB, 4 K in a 6-3 home loss April 17

Gallen (11-4, 3.18 ERA) makes his 22nd start. He has a 1.06 WHIP, 1.8 BB/9 and 9.3 K/9 in 130 1/3 innings.

  • Last start: No-decision, 7 IP, 3 ER, 5 H, 0 BB, 5 K in a 7-5 road loss vs. the Atlanta Braves last Thursday
  • 2023 home splits: 9-0, 1.48 ERA (67 IP, 11 ER – 3 HR), .198 OBA in 10 starts

Cardinals at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:02 a.m. ET.

  • Moneyline (ML): Cardinals +125 (bet $100 to win $125) | Diamondbacks -155 (bet $155 to win $100)
  • Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-155) | Diamondbacks -1.5 (+125)
  • Over/Under (O/U): 8.5 (O: -120 | U: +100)

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Cardinals at Diamondbacks picks and predictions

Prediction

Diamondbacks 4, Cardinals 2

Moneyline

The DIAMONDBACKS (-155) are a slam-dunk play in the series finale behind the All-Star starter Gallen. In fact, it’s a bit surprising that this number is not a little higher.

Gallen is a dominant 9-0 with a minuscule 1.48 ERA in 10 home outings, and 9 of his 10 home outings have resulted in quality starts, too. The Cardinals (+125) will be on the short end in this getaway day game.

Run line/Against the spread

The DIAMONDBACKS -1.5 (+125) are a little more risky of a play on the run line, as they’re still just 1-5 in the last 6 games overall.

Arizona is also 1-5 in the last 6 games on the run line at home, losing 4 of the outings outright. Still, it covered Gallen’s only start during that stretch, and the Snakes have covered 3 straight games at home as a favorite with the All-Star on the mound.

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Over/Under

UNDER 8.5 (+100) is worth a look with Gallen on the bump. He has allowed 3 or fewer runs in 3 straight starts, and 5 of the previous 7 outings, too.

The Over has cashed in 4 of the last 6 starts for Flaherty, but the Under is 3-1 in his last 4 road outings.

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St. Louis Cardinals at Arizona Diamondbacks odds, picks and predictions

Analyzing Tuesday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with MLB expert picks, predictions and best bets.

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The St. Louis Cardinals (45-56) are at the Arizona Diamondbacks (54-47)  on Tuesday for the 2nd game of their 3-game series. First pitch from Chase Field at 9:40 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Cardinals vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

The Cardinals took the opener 10-6, scoring 5 runs in the 9th inning to snap a 3-game losing streak.  St. Louis is 7-3 in its last 10 games.

The D-backs’ loss on Monday was their 5th in a row and they are 2-9 in their last 11 games. They are tied for 2nd place in the NL West with the San Francisco Giants, 4 games behind the division-leading Los Angeles Dodgers.

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Cardinals at Diamondbacks projected starters

LHP Steven Matz vs. RHP Merrill Kelly

Matz (1-7, 4.25 ERA) makes his 14th start and 22nd appearance. He has a 1.47 WHIP, 3.2 BB/9 and 8.8 K/9 in 81 innings.

  • Last start: Win, 5 IP. 1 ER, 3 H, 1 BB, 6 K in 7-2 road win over Chicago Cubs on Thursday
  • Cardinals are 3-0 in his 3 starts since returning to the rotation after being moved to the bullpen from the end of May to July 9

Kelly (9-4, 3.22 ERA) makes his 17th start. He has a 1.14 WHIP, 3.5 BB/9 and 9.3 K/9 in 95 innings.

  • Making 1st start since landing on injured list on June 27 with a blood clot
  • His 1st win of 2023 was April 17 on the road against the Cardinals, pitching 6 IP, allowing 1 ER, 5 H, 0 BB and 3 K in 6-3 victory

Cardinals at Diamondbacks odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:02 a.m. ET.

  • Moneyline (ML): Cardinals +116 (bet $100 to win $116) | Diamondbacks -134 (bet $134 to win $100)
  • Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-182) | Diamondbacks -1.5 (+150)
  • Over/Under (O/U): 9 (O: -105 | U: -115)

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Cardinals at Diamondbacks picks and predictions

Prediction

Diamondbacks 6, Cardinals 5

Moneyline

The Diamondbacks have lost 5 games in a row, their longest losing streak of the season. Before Kelly landed on IL, they won 6 of his last 8 starts.

The Cardinals, even with the win on Monday, are only 23-30 on the road, but are 5-4 in their last 9 road contests.

The Cardinals have won Matz’s last 3 starts, but are 5-8 overall when he starts.

And while the 12 of the Diamondbacks’ 1ast 13 wins are by more than 1 run, the bullpen has allowed at least 4 runs in 4 of their last 5 games, making it hard to trust they can cover the spread.

BET DIAMONDBACKS (-134).

Run line/Against the spread

The Cardinals are 30-23 ATS on the road this season and 3-2 ATS on their current road trip. Arizona is 24-27 ATS at home while 26-25 straight up at Chase Field. And 3 of the Cardinals’ last 6 losses have been by 1 run.

But at -182 for the Cardinals to cover, you’re better sticking with Arizona on the moneyline.

PASS. 

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Over/Under

Six of the Diamondbacks’ last 8 games have had 10 or more total runs while 7 of the Cardinals’ last 11 games have had at least 10 total runs.

BET OVER 9 (-105).

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St. Louis Cardinals at Arizona Diamondbacks odds, picks and predictions

Analyzing Monday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with MLB expert picks, predictions and best bets.

The Arizona Diamondbacks (54-46) welcome the St. Louis Cardinals (44-56) to Chase Field Monday. First pitch for the opener of this 3-game series is set for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Cardinals vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Diamondbacks lead 2-1

The Diamondbacks enter on a 4-game losing streak after getting swept in 3 at the Cincinnati Reds and are 2-8 over their last 10 (since the All-Star break). Arizona is 26-24 at home and 4 games behind the Los Angeles Dodgers for the top spot in the NL West.

The Cardinals are 6-4 since the break but have lost 3 in a row. They just dropped 3 of 4 at the Chicago Cubs, losing the series finale 7-2 Sunday. St. Louis is 22-30 on the road and 11 games back in the NL Central.

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Cardinals at Diamondbacks projected starters

RHP Adam Wainwright vs. TBD

Wainwright (3-4, 7.66 ERA) is expected to come off the injured list (shoulder irritation) to make his 12th start of the season. He has a 1.99 WHIP, 3.3 BB/9 and 4.9 K/9 through 51 2/3 innings.

  • Last start: Loss, 3 1/3 IP, 7 R (4 ER), 7 H, 2 BB, 3 K in 15-2 loss at Miami Marlins July 4
  • Last 3 starts: Allowed 4 or more ER in 3 straight games, 0-3, 19.13 ERA (8 IP, 17 ER)
  • Cardinals are 4-7 in his 11 starts, yet 3-2 in his 5 road starts
  • Career vs. D-backs: 11-6, 3.35 ERA (99 1/3 IP, 37 ER), including 0-1 in 1 start last year (6 IP, 3 ER, 4 H, 5 BB, 4 K in 6-2 home loss)

Arizona hasn’t officially named a starting pitcher, but all signs point to RHP Ryne Nelson (6-5, 4.82 ERA) being given the nod. He has a 1.38 WHIP, 2.5 BB/9 and 6.2 K/9 in 106 1/3 innings (20 starts).

  • Last start: Win, 7 IP, 2 ER, 3 H, 1 BB, 5 K in 5-3 victory at Atlanta Braves Wednesday
  • Been on fire lately, yielding 2 or fewer ER in 4 of last 5 starts
  • Home splits: 2-4, 8.08 ERA (42 1/3 IP, 38 ER) in 9 starts
  • Never faced Cardinals before

Cardinals at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 3:27 p.m. ET.

  • Moneyline (ML): Cardinals +115 (bet $100 to win $115) | Diamondbacks -140 (bet $140 to win $100)
  • Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-165) | Diamondbacks -1.5 (+135)
  • Over/Under (O/U): 10 (O: -105 | U: -115)

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Cardinals at Diamondbacks picks and predictions

Prediction

Diamondbacks 6, Cardinals 3

Moneyline

BET DIAMONDBACKS (-140).

Arizona has been terrific this season as an ML favorite, going 30-18, according to Teamrankings.com.

It gets even better as a home favorite, in which the organization is 18-10 straight up. With Nelson likely on the mound and pitching well, the Diamondbacks are bound to bounce back after getting swept this past weekend.

St. Louis is 12-16 as a road underdog. The Cardinals are also just 24-31 following a loss, which is the case since they lost at Wrigley Field Sunday.

With the difference in pitchers and performances trends, TAKE DIAMONDBACKS (-140).

Run line/Against the spread

PASS.

There’s no real value here. The Diamondbacks haven’t been great at home and aren’t performing well, so backing them to win by more than a run isn’t quite worth the risk at just +135.

Similarly, Wainwright hasn’t pitched in 20 days and could struggle to contain Arizona. St. Louis getting 1.5 runs is not worth the juice at -165. Ultimately, play Arizona ML to win outright for the best team-specific wager.

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Over/Under

LEAN UNDER 10 (-115).

Arizona’s Under at home has been a consistently good bet this season as the D-backs feature a 19-27-4 O/U home record.

While St. Louis is 49-46-5 on the Over, it’s just 24-29-2 O/U following a loss. Wainwright is rested, which may aid his performance, and Nelson has been dealing lately.

BACK UNDER 10 (-115).

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St. Louis Cardinals at Arizona Diamondbacks odds, picks and predictions

Analyzing Sunday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with MLB expert picks and predictions.

The St. Louis Cardinals (68-51) go for the sweep against the Arizona Diamondbacks (55-65) Sunday in the finale of a 3-game set at Chase Field. First pitch is set for 4:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Cardinals vs. Diamondbacks odds with MLB picks and predictions.

Season series: Cardinals lead 4-2

The Cardinals are clicking on all cylinders with 6 wins in a row. They mashed their way to victory Saturday night in a 16-7 rout that saw DH Albert Pujols hit career home runs No. 691 and 692. The Cards have won 16 of 20, and it will take a buzzsaw to slow them down.

The D-backs have played inspired ball with a 16-14 record in the last 30 games, despite dropping 2 in a row in this series. They’re 32-31 at home, which is good for a team 10 games below .500. Arizona is 17-15 against left-handed pitchers, which is what it’s up against Sunday.

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Cardinals at Diamondbacks projected starters

LHP Jose Quintana vs. RHP  Merrill Kelly

Quintana (4-5, 3.38 ERA) makes his 24th start of the season. He has a 1.24 WHIP, 2.8 BB/9 and 7.9 K/9 in 120 IP.

  • Is 1-0 with a 2.65 ERA, 1.06 WHIP and 8.5 K/9 in 3 starts with Cardinals
  • Has a 4.93 ERA, 1.42 WHIP and 7.1 K/9 on road vs. 2.42 ERA, 1.13 WHIP and 8.4 K/9 in home games

Kelly (10-5, 2.81 ERA) makes his 25th start of the season. He has a 1.12 WHIP, 2.7 BB/9 and 7.6 K/9 in 144 1/3 IP.

  • Has a 1.53 ERA in his last 7 starts
  • Allowed 2 H in 7 shutout IP with 4 K April 20 vs. the Cardinals

Cardinals at Diamondbacks odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:05 a.m. ET.

  • Money line (ML): Cardinals -130 (bet $130 to win $100) | Diamondbacks +105 (bet $100 to win $105)
  • Run line (RL)/Against the spread (ATS): Cardinals -1.5 (+130) | Diamondbacks +1.5 (-160)
  • Over/Under (O/U): 7.5 (O: -112 | U: -108)

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Cardinals at Diamondbacks picks and predictions

Prediction

Cardinals 3, Diamondbacks 2

Money line

Kelly has been phenomenal over the last 6 weeks, but he’s facing a different kind of beast in St. Louis. Cards 3B Nolan Arenado is 5-for-10 (.500) with 4 doubles in the 2 games of this series. He’s 3-for-7 (.429) with a double and a homer against Kelly in his career and worth consideration for a prop bet once they become available closer to first pitch. Take the CARDINALS (-130) for the sweep.

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Run line/Against the spread

The Diamondbacks are worth a look here on the run line because Kelly has been so good and shut down a lesser version of the Cardinals in April. The D-backs are 35-28 on the RL at home this year, but are just 15-22 in 1-run games. The Cards emptied their pen Saturday and are without closer Ryan Helsley. Thus, LEAN DIAMONDBACKS +1.5 (-160) for a HALF-UNIT.

Over/Under

I like the Under here, but as mentioned, the bullpens are pretty weary. The Under is 4-0 in the Diamondbacks’ last 4 games with the total set between 7.0-8.5. The Under hit Friday, and after the explosion from Saturday, pitching is bound to reel things in. LEAN UNDER 7.5 (-108).

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St. Louis Cardinals at Arizona Diamondbacks odds, picks and prediction

Analyzing Friday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with MLB picks and predictions.

The St. Louis Cardinals (28-22) face the Arizona Diamondbacks (18-33) for the second of a four-game series Friday night with a 9:40 p.m. ET first pitch at Chase Field. Let’s analyze BetMGM Sportsbook‘s lines around the Cardinals vs. Diamondbacks odds with MLB picks and predictions.

RHP Johan Oviedo is the projected starting pitcher for the Cardinals. He is 0-2 with a 5.74 ERA, 1.34 WHIP, 7.5 K/9 and 5.2 BB/9 in 15 2/3 IP over 3 starts and 1 relief appearance. He is making his first start since May 14 after a stint in the minor leagues. He lasted only two-plus innings in his last start in the majors, giving up 3 runs on 2 hits and walking 5 without a strikeout.

LHP Madison Bumgarner is the projected starting pitcher for the Diamondbacks. He is 4-4 with a 4.53 ERA, 1.08 WHIP, 9.4 K/9 and 2.3 BB/9 in 53 2/3 IP over 10 starts. Bumgarner has lost his last 2 starts, allowing 9 runs (7 earned) over 10 innings. He is 2-1 with a 3.78 ERA at Chase Field this year.

MLB betting offers/promotions

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Cardinals at Diamondbacks odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 10:28 a.m. ET.

  • Money line: Cardinals +105 (bet $100 to win $105) | Diamondbacks -130 (bet $130 to win $100)
  • Against the spread/ATS: Cardinals +1.5 (-175) | Diamondbacks -1.5 (+145)
  • Over/Under: 9 (O: -120 | U: +100)

Prediction

Cardinals 5, Diamondbacks 2

Money line (ML)

The Diamondbacks have lost 11 straight games and 14 of their last 15 contests. They have scored only 24 runs in the losing streak and have allowed 58. They are better at Chase Field (9-12) than they have been on the road (9-21).

The Cardinals have won 2 in a row, but prior had lost 3 straight and 7 of their last 10. They picked up a 5-4 10-inning win over Arizona Thursday night.

Until the Diamondbacks figure things out it’s hard to back them, take the CARDINALS (+105).

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Run line/Against the spread (ATS)

Despite their overall record, the Diamondbacks are 27-24 ATS this season. They have been 1.5-run dogs in 13 of their last 14 games and have covered the spread in only 5 of those games.

The Cardinals are 4-7 ATS in their last 11 games and failed to cover the 1.5-run line Thursday night, with a one-run win in extra innings. They are 15-10 ATS this season on the road.

Right now, it is a good bet to ride with whomever the Diamondbacks are playing. Take the CARDINALS +1.5 (-175).

Over/Under (O/U)

The Diamondbacks have scored 4 runs in two consecutive games but have scored 2 or fewer runs in 7 games of their 11-game skid. They are 2-8-1 O/U in their last 11.

They scored 5 runs to beat the D-Backs in extra innings on Thursday, but before that the Cardinals had scored 3 or fewer runs in 5 of 6 games. Five of their last six games have gone Under the total as well.

Take UNDER 9 RUNS (+100).

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St. Louis Cardinals at Arizona Diamondbacks odds, picks and prediction

Analyzing Thursday’s St. Louis Cardinals at Arizona Diamondbacks odds and lines, with MLB picks and predictions.

The St. Louis Cardinals (27-22) begin a four-game series with the Arizona Diamondbacks (18-32) Thursday at Chase Field. First pitch is scheduled for 9:40 p.m. ET. Let’s analyze BetMGM Sportsbook‘s lines around the Cardinals vs. Diamondbacks odds with MLB picks and predictions.

St. Louis prevented a three-game sweep by the Chicago White Sox with a 4-0 win Wednesday but is just 4-6 in the last 10 games.

Arizona is ice-cold right now with 10 straight losses, including a 5-4 loss Wednesday to the San Francisco Giants in which the D-Backs held a four-run lead after the second inning.

Season series: 0-0.

RHP Carlos Martinez is the projected starter for the Cardinals. He is 3-4 with a 4.18 ERA (47 1/3 IP, 22 ER), 1.12 WHIP, 2.9 BB/9 and 4.6 K/9 through eight starts.

  • Last outing: No-decision in 6 IP with 2 ER, 4 H, 1 BB and 2 K vs. the Chicago Cubs Friday.
  • Career vs. D-Backs: 3-1 with a 2.51 ERA (43 IP, 12 ER), 1.07 WHIP and 9.0 K/9 across six starts and six relief appearances.
    • vs. D-Backs on the current roster: 56 at-bats with a .179/.270/.250 slash line, 17/6 K/BB, 0 HR and 3 RBIs.

RHP Matt Peacock makes his third career start for the D-Backs. He is 1-1 with a 4.91 ERA (22 IP, 12 ER), 1.09 WHIP, 1.2 BB/9 and 6.1 K/9 in two starts and eight relief appearances.

  • Last outing: No-decision in 5 1/3 IP with 1 ER, 4 H, 0 BB and 4 K in Arizona’s 4-2 loss at the Los Angeles Dodgers last Wednesday.

MLB betting offers/promotions

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Cardinals at Diamondbacks odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 11:40 a.m. ET.

  • Money line: Cardinals -110 (bet $110 to win $100) | Diamondbacks -110 (bet $110 to win $100)
  • Against the spread/ATS: Cardinals -1.5 (+140) | Diamondbacks +1.5 (-165)
  • Over/Under: 9.5 (O: +100 | U: -120)

Prediction

Cardinals 11, Diamondbacks 2

Money line (ML)

BET the CARDINALS (-110) for 1 unit because I really like St. Louis’ odds off drilling Arizona’s starter, Martinez’s splits against the D-Backs are impressive and Arizona’s bullpen has the worst WAR in the majors.

Peacock doesn’t strike out a lot of batters—he grades in the 9th-percentile of K%, 2nd-percentile of whiff rate and 4th-percentile of chase rate—and he gives up a lot of hard contact (17th percentile in hard-hit rate and 35th percentile in exit velocity).

The Cardinals’ lineup has the fifth-highest contact rate and the eighth-lowest swinging strike rate. Also, Peacock’s most used pitch in his arsenal is his sinker and the heart of the St. Louis order hits the sinker well.

The two through four hitters (RF Dylan Carson, 1B Paul Goldschmidt and 3B Nolan Arenado) all have a plus-3 or higher run value vs. sinkers with a 42.4% or higher hard-hit rate and .433 or better wOBA.

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Run line/Against the spread (ATS)

“LEAN” to the CARDINALS -1.5 (+140) for a half unit because of the aforementioned reasons and we are getting a fluffy payout.

Additionally, St. Louis is 4-1 on the run line when favored on the road and Arizona is 6-7 ATS as a home dog.

Over/Under (O/U)

Slight “LEAN” to the OVER 9.5 (+100) for a quarter unit because the St. Louis lineup is in a good spot for a big day and both teams’ situational trends skew toward the Overt.

I wouldn’t bet the Over too heavily because Martinez has good numbers against the D-Backs and he has had a quality start in four of his past five outings.

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