The Arizona Cardinals (4-12) wrap up their season on the road in Week 18 against the NFC West champion San Francisco 49ers (12-4). Sunday’s kickoff at Levis Stadium is at 4:25 p.m. ET (FOX). Below, we analyze Tipico Sportsbook’s lines around the Cardinals vs. 49ers odds, and make our expert NFL picks and predictions.
The Cardinals have lost 6 straight games and 8 of their last 9. They lost 20-19 last week to the Atlanta Falcons on the final play of the game, but did cover the 7-point spread as road underdogs. After starting 4 different QBs in 4 games, David Blough will make his 2nd consecutive start.
The 49ers head to the postseason with a shot at the No. 1 seed in the NFC. They have won 9 consecutive games and the last 4 with 7th-round rookie QB Brock Purdy starting in place of the injured Jimmy Garoppolo. They picked up a 37-34 overtime win over the Las Vegas Raiders last week, but failed to cover the 10-point spread as road favorites.
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Cardinals at 49ers odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:33 a.m. ET.
- Moneyline (ML): Cardinals +800 (bet $100 to win $800) | 49ers -1200 (bet $1200 to win $100)
- Against the spread (ATS): Cardinals +14 (-108) | 49ers -14 (-112)
- Over/Under (O/U): 39.5 (O: -111 | U: -109)
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Cardinals at 49ers key injuries
Cardinals
- DL Zach Allen (hand) out
- LB Zaven Collins (calf) out
- RB James Conner (shin) out
- DL Leki Fotu (shoulder) questionable
- CB Antonio Hamilton (hip) out
- WR DeAndre Hopkins (knee) out
- QB Colt McCoy (concussion) out
- CB Marco Wilson (neck) out
49ers
- DT Arik Armstead (foot, ankle, illness) questionable
- OL Aaron Banks (ankle, knee) out
- QB Jimmy Garoppolo (foot) out
- DT Kenny Givens (knee) out
- LB Dre Greenlaw (back) out
- DT Javon Kinlaw (knee, illness) questionable
- CB Ambry Thomas (ankle) out
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Cardinals at 49ers picks and predictions
Prediction
49ers 31, Cardinals 13
Moneyline
The Cardinals have a 4th-string QB starting without many of their starters. Their season is over.
The 49ers are trying to play for the No. 1 seed. They have won 9 straight.
The Cardinals have no incentive to win, but there is no reason to bet the 49ers on the moneyline.
PASS.
Against the spread
The 49ers are 10-6 ATS and, before failing to cover the spread in their win over the Raiders last week, they had covered the spread in 6 straight.
They beat the Cardinals by 28 in Week 11 in Mexico City (38-10).
The Cardinals have covered the spread the last 2 weeks, but were going against a bad defense in Atlanta and a bad offense against Tampa Bay. The Cardinals will not be able to do much this week.
BET 49ERS -14 (-112).
Over/Under
The 49ers have the league’s No. 1 defense. Outside of allowing 34 points last week, in the previous 8 games they allowed 12.1 points per game.
The Cardinals have failed to score 20 points in 5 of their last 6 while the Niners have scored over 30 in 5 of their last 7 games.
BET OVER 39.5 (-111).
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