The Buffalo Bills (10-3) visit the Denver Broncos (5-8) Saturday for a 4:30 p.m. ET kickoff at Empower Field at Mile High in Denver. Below, we preview the Bills-Broncos betting odds and lines and make our NFL picks and predictions.
Bills at Broncos: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 9:35 a.m. ET.
- Money line: Bills -275 (bet $275 to win $100) | Broncos +225 (bet $100 to win $225)
- Against the spread/ATS: Bills -6 (-110) | Broncos +6 (-110)
- Over/Under: 49.5 (O: -115 | U: -105)
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Bills at Broncos: Game notes
- The Bills are coming off an impressive 26-15 victory on Sunday Night Football over the Pittsburgh Steelers. They won for the sixth time in seven outings while covering the spread for the fifth consecutive contest. The Bills are also averaging 30.8 points per game over their past six games, which is more than three points better than their overall season average of 27.6 PPG which ranks ninth in the NFL.
- The Broncos won 32-27 in a road win over the Carolina Panthers last Sunday. It was their second-highest point total of the season. The Broncos have a respectable 2-2 record over their past four games, including a 20-13 win in Week 11 over the playoff-hopeful Miami Dolphins. Denver is also 3-1 ATS across its past four.
- The Broncos defense has held them in most games, as they yield just 351.7 total yards per game to rank 16th. While that’s a bit mediocre, they’re ninth in the NFL against the pass, allowing just 220.7 yards per game.
- A big reason for the lack of success for the Broncos is their inability to take care of the ball. They have forced just 11 takeaways while posting a league-high 21 interceptions with eight fumbles lost. That’s good for a dismal minus-18 turnover differential, which is eight worse than the next-worst teams.
- On the flip side, the Bills have forced 21 turnovers with 19 miscues, good for a plus-2 turnover differential.
Bills at Broncos: Key injuries
Bills
- S Jaquan Johnson (ankle) out
- TE Lee Smith (knee) questionable
Broncos
- OG Graham Glasgow (foot) questionable
- RB Melvin Gordon III (shoulder) questionable
- RB Phillip Lindsay (hip) questionable
- S Trey Marshall (shin) questionable
Bills at Broncos: Odds, betting lines, predictions and picks
Prediction
Bills 27, Broncos 16
Money line (?)
The Bills (-275) are going to win this game on the road, pushing past the Broncos, who are going nowhere. Risking nearly three times your potential return is not the way to go.
PASS.
Against the spread (?)
The BILLS -6 (-110) are an attractive play under a flat 7, especially on the road. Buffalo has won just two of its past four games on the road, although if you ask anyone in Bills Mafia, they’ll let you know they got jobbed against the Arizona Cardinals in Week 10, a 32-30 loss on a Hail Murray … err, Hail Mary.
The Broncos have posted a 2-4 SU/3-3 ATS mark in six games at Mile High. While their Week 12 game against the Saints can be tossed out, as the NFL left them high and dry without a professional quarterback due to COVID-19 in the QB room, they’re still sub-.500 at home. This is a team which is making strides down the stretch, but they’re not in the same league as the Bills quite yet.
Over/Under (?)
UNDER 49.5 (-105) is the lean, as Buffalo’s defense last week finally looked like its 2019 version, which was championship caliber. The Bills have allowed 18.7 PPG across their past three outings, which is 6 points better than its overall season average of 24.7 PPG allowed.
They’ll force Broncos QB Drew Lock into his share of mistakes, and defense will rule the day in this one.
Want action on this NFL game? Sign up and bet at BetMGM. If you’re looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Also see:
- Denver wants to mimic this part of Allen’s development with Lock (Bills Wire)
- Pat McAfee helped the Broncos find their emergency kicker (Broncos Wire)
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