49ers Vikings odds picks prediction spread over/under betting line

San Francisco 49ers at Minnesota Vikings odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Minnesota Vikings odds and lines, with expert NFL picks and predictions.

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The Minnesota Vikings (1-0) welcome the San Francisco 49ers (1-0) to U.S. Bank Stadium Sunday. Kickoff is set for 1 p.m. ET (CBS). Let’s analyze BetMGM Sportsbook’s NFL odds around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.

The Vikings clobbered the New York Giants on the road in Week 1, winning 28-6 and covering as 1-point favorites. In its Week 1 battle, RB Aaron Jones led the way with 94 rushing yards and a TD on 14 carries. Former top-5 pick QB Sam Darnold ended with 208 yards, 2 TDs and an INT.

The 49ers beat up the visiting New York Jets 32-19 in Week 1 action, covering as 3.5-point favorites. They used a 13-0 second quarter to pull away in the Monday Night Football showdown. The 49ers were led by RB Jordan Mason, who rushed for 147 yards and a score on 28 carries — RB Christian McCaffrey was a late scratch.

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49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Friday at 9:05 p.m. ET.

Moneyline (ML): 49ers -225 (bet $225 to win $100) | Vikings +185 (bet $100 to win $185)
Against the spread (ATS): 49ers -4.5 (-110) | Vikings +4.5 (-110)
Over/Under (O/U): 46.5 (O: -110 | U: -110)

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49ers at Vikings key injuries

Vikings

WR Jordan Addison (ankle) out
TE T.J. Hockenson (knee) out
QB J.J. McCarthy (knee) out
T Brian O’Neill (elbow) questionable
S Harrison Smith (hip) questionable

49ers

S Talanoa Hufanga (knee) doubtful
RB Christian McCaffrey (calf) out
WR Ricky Pearsall (chest/shoulder) out

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49ers at Vikings picks and predictions

Prediction

49ers 28, Vikings 23

Moneyline

PASS.

The 49ers (-225) are a well-coached, well-oiled machine and should be able to come out on top; however, they are too expensive to take on the moneyline.

Against the spread

BET 49ERS -4.5 (-110).

The Vikings throttled the Giants, who could be the worst team in the NFL. Darnold still had an interception and hasn’t proven he can consistently perform without turning the ball over. The 49ers have one of the best offensive lines in the NFL and should be able to find traction against a weak Vikings defensive line.

The 49ers went for over 220 rushing yards in Week 1 and are taking on a front ranked as the 30th-best unit in the NFL by PFF.com. Expect San Francisco to enforce its will in the trenches and ultimately cover. Both teams are entering 1-0 ATS.

Take 49ERS -4.5 (-110).

Over/Under

BET OVER 46.5 (-110).

There are playmakers on both sides of the ball that should do just that Sunday. The Vikings have a few superstars in Jones and WR Justin Jefferson, who both scored against the Giants. While Darnold isn’t great, he is serviceable and should be able to find his weapons.

The 49ers put up 32 points on one of the best defenses in the NFL and have the firepower to do that against a weaker Vikings side. Minnesota is 0-1 O/U due to the Giants putting up just 6 points. The 49ers are 1-0 O/U and were 12-8 O/U last season with a similar roster.

Take OVER 46.5 (-110).

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First look: San Francisco 49ers at Minnesota Vikings odds and lines

Looking at Sunday’s San Francisco 49ers at Minnesota Vikings Week 2 NFL odds, lines and trends. Here’s what you need to know.

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The San Francisco 49ers (1-0) and the Minnesota Vikings (1-0) meet in Week 2 at U.S. Bank Stadium in Minneapolis. Kickoff is scheduled for 1 p.m. ET (CBS). Below, we look at 49ers vs. Vikings odds from BetMGM Sportsbook’s NFL odds before making our expert NFL picks and predictions later in the week.

The 49ers were without RB Christian McCaffrey for Week 1 due to Achilles’ and calf injuries, but RB Jordan Mason stepped in for his 1st NFL start, and his 1st NFL 100-yard game. Mason ended up with 147 rushing yards and a score in a 32-19 victory over the New York Jets, which was a Scorigami, by the way.

There are reports McCaffrey might sit again in Week 2 due to the artificial turf at U.S. Bank Stadium, so that’s something to watch during the week.

The Vikings paddled the hapless New York Giants 28-6 on the road Sunday in their opener, as QB Sam Darnold tossed 2 TDs, including 1 to superstar WR Justin Jefferson. Unlike the 49ers, the Vikings cashed low on the total in Week 1. Now, Darnold makes his home debut for the Vikings against his 2023 team.

49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of NFL odds. Lines last updated Tuesday at 6:11 a.m. ET.

Moneyline (ML): 49ers -275 (bet $275 to win $100) | Vikings +220 (bet $100 to win $220)
Against the spread (ATS): 49ers -6 (-110) | Vikings +6 (-110)
Over/Under (O/U): 45.5 (O: -110 | U: -110)

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2024 betting stats

ML: 49ers 1-0 | Vikings 1-0
ATS: 49ers 1-0 | Vikings 1-0
O/U: 49ers 1-0 | Vikings 0-1

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49ers vs. Vikings head-to-head

This will be the 10th meeting since 2006. Minnesota holds a 5-4 edge in the series during the span. The home side has won 7 straight meetings, with the home team also 6-0 ATS in the previous 6 in this series.

These teams met last season in the Twin Cities, with Minnesota winning 22-17 as a 6.5-point underdog as the Under (44) cashed on Oct. 23, 2023. The Under is 5-1 in the past 6 meetings, and 7-2 in the previous 9 in the series, including the past 3 battles in the Twin Cities.

The teams have played 50 times (6 in the postseason) with the 49ers ahead 25-24-1.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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San Francisco 49ers at Minnesota Vikings odds, picks and predictions

Analyzing Monday’s San Francisco 49ers at Minnesota Vikings odds and lines, with expert NFL picks and predictions.

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The San Francisco 49ers (5-1) face the Minnesota Vikings (2-4) at 8:15 p.m. ET Monday at U.S. Bank Stadium (ABC/ESPN). Below, we analyze BetMGM Sportsbook’s lines around the 49ers vs. Vikings odds, and make our expert NFL picks and predictions.

After scoring 30 or more points in each of their first 5 games, the 49ers were shut down by the Browns 19-17 on Oct. 15 in the worst game of QB Brock Purdy‘s career. He completed just 12 of 27 passes for 125 yards with 1 touchdown and 1 interception. The 49ers are 4-2 against the spread (ATS).

The Vikings kept hope alive for their season with a 19-13 win over the Chicago Bears. The Vikings defense knocked Bears QB Justin Fields out of the game and needed a defensive touchdown from LB Jordan Hicks to lock down the win and improve Minnesota to 2-3-1 ATS.

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49ers at Vikings odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 10:13 p.m. ET.

Moneyline (ML): 49ers -300 (bet $300 to win $100) | Vikings +240 (bet $100 to win $240)
Against the spread (ATS): 49ers -7 (-105) | Vikings +7 (-115)
Over/Under (O/U): 43 (O: -110 | U: -110)

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49ers at Vikings key injuries

49ers

LB Dre Greenlaw (hamstring) questionable
RB Christian McCaffrey (oblique) questionable
WR Deebo Samuel (shoulder) out
OT Trent Williams (ankle) doubtful

Vikings

G Ezra Cleveland (foot) out

49ers at Vikings picks and predictions

Prediction

49ers 31, Vikings 17

Moneyline

PASS.

The 49ers should win this one with relative ease — even if their injured stars don’t play or are limited. But a 1:3 ratio for return on investment is too steep a price to pay.

Against the spread

TAKE 49ERS -7 (-105).

The 49ers are the best team in the NFC and can dominate on both sides of the ball. The Vikings and QB Kirk Cousins have struggled badly in prime-time games, and without Justin Jefferson, the team is without its most dynamic player.

The 49ers are capable of blowing the doors off the Vikings, even if McCaffrey is out or limited. The Vikings are among the worst teams in the league in terms of turnovers (13), and the 49ers lead the league in giveaway/takeaway ratio (plus-8). That’s a bad combination for the Vikings.

Over/Under

TAKE OVER 43 (-110).

The 49ers have scored 30 or more points in 5 of 6 games and have a good chance of doing that against Minnesota’s risk-taking, blitz-happy defense. Big plays will be available to the 49ers offense if the line can pick up Minnesota’s blitzes.

San Francisco has outscored its opponents 41-6 in the 1st quarter this season and 106-54 in the 1st half. If the Vikings get behind, they will become 1-dimensional and could end up passing 40 or more times. That should help give them enough points to do their part to get this score Over.

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