The San Francisco 49ers (5-4) and Arizona Cardinals (4-6) face off in the NFL’s final international game of the season. They play Monday night at Estadio Azteca in Mexico City with kickoff at 8:15 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Cardinals odds, and make our expert NFL picks and predictions.
The Cardinals beat the Rams 27-17 in Week 10 as 3.5-point underdogs. QB Colt McCoy, starting in place of an injured Kyler Murray, threw a TD pass and RB James Conner rushed for 2 TDs. The win snapped a 2-game losing streak.
The 49ers beat the Los Angeles Chargers 22-16 last week but failed to cover the 8.5-point spread as favorites. They have won 2 straight games and are undefeated in NFC West games.
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49ers vs. Cardinals odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:57 p.m. ET.
- Moneyline (ML): 49ers -455 (bet $455 to win $100) | Cardinals +350 (bet $100 to win $350)
- Against the spread (ATS): 49ers -10 (-110) | Cardinals +10 (-110)
- Over/Under (O/U): 43 (O: -110 | U: -110)
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49ers vs. Cardinals key injuries
49ers
- DT Arik Armstead (foot, ankle) out
- DE Samson Ebukam (quadriceps, Achilles) questionable
Cardinals
- TE Zach Ertz (knee) out
- OL Max Garcia (shoulder) out
- WR DeAndre Hopkins (hamstring) questionable
- OL D.J. Humphries (back) out
- CB Byron Murphy (back) out
- QB Kyler Murray (hamstring) out
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49ers vs. Cardinals picks and predictions
Prediction
49ers 24, Cardinals 20
Moneyline
The Cardinals swept the Niners last season and have won 3 of the last 4 meetings.
McCoy led the Cardinals to a 31-17 win last season in Santa Clara, so the Cardinals are capable of pulling off a win without Murray.
However, with four starting offensive linemen down, the 49ers’ pass rush will be too much and the run game will be hard to stop with Elijah Mitchell and Christian McCaffrey.
The 49ers allow the fewest yards in the NFL.
The 49ers should win, but PASS on the moneyline because there is better value elsewhere.
Against the spread
Up until last week’s win over the Chargers, the 49ers had covered the spread in every win this season.
The Cardinals are 5-5 ATS this season, covering the spread once in a loss.
The Cardinals historically play the 49ers tough and 10 points is a lot to lay in this game.
BET CARDINALS +10 (-110).
Over/Under
While the 49ers allow only an average of 18.1 points per game, the Cardinals are averaging 29.0 per game in their last 4 contests, which corresponds with the return of WR DeAndre Hopkins.
The Cardinals allow an average of 25.8 points per game.
BET OVER 43 (-110).
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