49ers Bears odds lines money line against the spread Over Under

San Francisco 49ers at Chicago Bears odds, picks and predictions

Analyzing Sunday’s San Francisco 49ers at Chicago Bears odds and lines, with expert NFL picks, predictions and best bets.

To kick off the 2022 NFL season, the San Francisco 49ers (0-0) are on the road to face the Chicago Bears (0-0) in an early game Sunday. Kickoff is at 1 p.m. ET at Soldier Field, and the game will air regionally on FOX. Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Bears odds, and make our expert NFL picks and predictions.

The 49ers are coming off a 10-win season, a trip to the playoffs and an appearance in the NFC Championship Game. The difference is that this year their starting quarterback will be 2021 No. 3 overall pick Trey Lance. Lance takes over for Jimmy Garoppolo, who remains on the team as a backup.

The Bears hired coach Matt Eberflus to groom second-year QB Justin Fields to be a franchise quarterback and get the team back to the postseason after a 6-11 2021 season.

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49ers at Bears odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 12:25 p.m. ET.

Money line (ML): 49ers -320 (bet $320 to win $100) | Bears +260 (bet $100 to win $260)
Against the spread (ATS): 49ers -6.5 (-120) | Bears +6.5 (+100)
Over/Under (O/U): 40.5 (O: -110 | U: -110)

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49ers at Bears key injuries

49ers

OL Daniel Brunskill (hamstring) out
TE George Kittle (groin) questionable

Bears

WR Velus Jones Jr. (hamstring) out
DE Dominique Robinson (knee) questionable

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49ers at Bears picks and predictions

Prediction

Bears 23, 49ers 19

Money line

Lance gets the keys to the offense despite Garoppolo’s presence on the roster. He was 31-14 as a starter. 49ers HC Kyle Shanahan is 8-28 when other players start at quarterback.

The Bears have a new offensive scheme, and Fields looked good in the preseason.

Lance is not the polished passer that Garoppolo is, and while he has a higher ceiling for his play, he will be more prone to mistakes, especially turning the ball over. And it appears they will be without Kittle for this game, although he is officially listed as questionable for the game. Kittle said he’s doing everything he can to play and felt better Friday.

With a new scheme and opening at home with the extra energy to start the season, I have this as one of my big underdog picks of the week.

Fade the 49ers and take the BEARS (+260) to win.

Against the spread

The 49ers were 12-8 ATS last season, including the postseason while the Bears were 6-11 ATS.

I personally like taking teams in their home opener to cover the spread, no matter how bad they appear to be.

The money line is where the money is, but the spread is large enough to give yourself breathing room.

Take the BEARS +6.5 (+100).

Over/Under

In 2021, the 49ers were 8-12 O/U, and the Bears were 7-10 O/U.

The Bears averaged more than 20 points in the preseason.

The 49ers scored 28 in their final preseason tuneup.

The projected total is a touch low so I like OVER 40.5 (-110).

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First look: San Francisco 49ers at Chicago Bears odds and lines

Looking at Sunday’s San Francisco 49ers at Chicago Bears Week 8 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (2-4) and Chicago Bears (3-4) meet Sunday in Week 8 for a 1 p.m. ET kickoff at Soldier Field. Below, we look at the 49ers vs. Bears odds and lines; check back for our NFL picks and predictions.

San Francisco lost its fourth in a row, suffering a 30-18 upset by the visiting Indianapolis Colts in a rain-soaked Sunday Night Football game in Week 7. The 49ers, who trailed 20-18 early in the fourth quarter, did not cover the spread as 3.5-point favorites.

QB Jimmy Garoppolo struggled in his return after missing one game with a calf injury. He completed 16 of 27 pass attempts for 181 yards with 1 touchdown and 2 interceptions. He also lost a fumble.

Chicago was drubbed 38-3 at the Tampa Bay Buccaneers Sunday. The Bears, who failed to cover as 12.5-point underdogs, had 5 turnovers as rookie QB Justin Fields threw 3 interceptions and lost 2 fumbles. The first-round draft pick passed for 184 yards with no TDs, while running for 38 yards on 8 carries. One bright spot was rookie RB rookie Khalil Herbert, who had a career-high 100 rushing yards on 18 carries.

Also see: All Week 8 odds and lines

49ers at Bears odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 10 a.m. ET.

Money line: 49ers -205 (bet $100 to win $205) | Bears +165 (bet $100 to win $165)
Against the spread (ATS): 49ers -3.5, -115 (bet $115 to win $100) | Bears +3.5, -105 (bet $105 to win $100)
Over/Under (O/U): 41.5, O: -112 (bet $112 to win $100) | U: -108 (bet $108 to win $100)

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2021 betting stats:

ML: 49ers 2-4 | Bears 3-4
ATS: 49ers 1-5 | Bears 3-4
O/U: 49ers 3-3 | Bears 1-6

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49ers at Bears head-to-head

San Francisco leads the all-time series 34-32-1 and is 3-0 vs. the Bears in the postseason.

It’s been pretty even since 2006 as the two split their eight meetings 4-4.

Chicago won 14-9 as a 4-point road favorite the last time they met back on Dec. 23, 2018.

San Francisco won 15-14 the last time they met at Soldier Field Dec. 3, 2017. Former Bears PK Robbie Gould kicked a 24-yard field goal with 4 seconds remaining for the 49ers as they pulled off the upset as 2.5-point dogs.

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