St. Louis Cardinals at Chicago Cubs odds, picks and predictions

Analyzing Thursday’s St. Louis Cardinals at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

The St. Louis Cardinals (43-53) visit the Chicago Cubs (45-50) on Thursday to kick off a 4-game series against their NL Central Division rival. First pitch from Wrigley Field is set for 8:05 p.m. ET (ESPN+). Let’s analyze BetMGM Sportsbook’s lines around the Cardinals vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cardinals lead 3-2

St. Louis won 6-4 as -107 home favorites Wednesday to complete a 3-game  sweep of the Miami Marlins. The Cardinals are on a 5-game win streak and sit at 21-27 on the road. St. Louis is 2 1/2 games behind the Cubs for 3rd place in the division.

Chicago beat the Washington Nationals 8-3 Wednesday as -146 home favorites to win the series 2-1. The game was tied at 3 when the Cubs scored 5 runs in the bottom of the 8th inning. The Cubs have won back-to-back games, but are only 5-5 in their last 10. Chicago is 24-25 at home on the year.

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Cardinals at Cubs projected starters

LHP Steven Matz vs. RHP Marcus Stroman

Matz (0-7, 4.86 ERA) makes his 13th start. He has a 1.51 WHIP, 3.3 BB/9 and 8.6 K/9 in 76 innings.

  • Last outing: No-decision, 4 1/3 IP, 4 ER, 4 H, 3 BB, 4 K in a 9-6 home win Saturday vs. the Washington Nationals
  • Career vs. Chicago (regular season): 0-2, 3.92 ERA (20 2/3 IP, 9 ER), 22 H, 7 BB, 20 K in 4 appearances (3 starts)

Stroman (10-6, 2.88 ERA) makes his 21st start. He has a 1.09 WHIP, 3.2 BB/9 and 7.7 K/9 in 118 2/3 innings.

  • Last outing: Win, 6 IP, 1 ER, 3 H, 1 BB, 3 K in a 10-4 home win Saturday vs. the Boston Red Sox
  • Career vs. St. Louis: 1-5, 4.96 ERA (49 IP, 27 ER), 61 H, 1.43 WHIP, 8.8 K/9 in 9 starts

Cardinals at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:28 a.m. ET.

  • Moneyline (ML): Cardinals +110 (bet $100 to win $110) | Cubs -130 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-190) | Cubs -1.5 (+155)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

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Cardinals at Cubs picks and predictions

Prediction

Cardinals 6, Cubs 4

Moneyline

BET CARDINALS (+110).

The Cardinals are 7-3 in the last 10 meetings and are the hotter team — on a 5-game win streak and 8-2 in their last 10. The Cubs are only 2-3 in Stroman’s last 5 starts and 0-3 in his last 3 starts vs. St. Louis. While Matz is 0-7, the Cardinals are 3-2 in his last 5 starts.

Run line/Against the spread

PASS.

St. Louis should cover here but at +1.5 (-190) the line is not worth the juice, bet on the moneyline and/or O/U instead.

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Over/Under

LEAN OVER 8.5 (-110).

The Over is 5-1 in the Cardinals’ last 6 games and 2-1 in Matz’s last 3 starts while the Over is 9-1 in the Cubs’ last 10 games inclduing 8 straight. Also, the Over is also 2-0 in Stroman’s last 2 starts.

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