St. Louis Cardinals at Chicago Cubs odds, picks and predictions

Analyzing Sunday’s St. Louis Cardinals at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The St. Louis Cardinals (34-35) and Chicago Cubs (34-37) finish their 3-game series at Wrigley Field on Sunday. First pitch is scheduled for 1:05 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Cardinals vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Cardinals lead 3-1

After losing 3-0 on Friday, the Cubs won 5-1 on Saturday as LHP Shota Imanaga continues to be Chicago’s most valuable player. He is 7-1 with a 1.89 ERA and 0.99 WHIP. On Saturday he threw 7 innings, giving up 4 H, 1 ER, 0 BB with 6 K.

The only Cardinal run was a sacrifice by 3B Nolan Arenado in the 4th inning. But in the bottom of the inning, the Cubs responded with 2 runs and went on to win as -185 favorites.

Cardinals at Cubs projected starters

RHP Miles Mikolas vs. RHP Jameson Taillon

Mikolas (4-6, 4.85 ERA) makes his 15th start. He has a 1.19 WHIP, 1.7 BB/9 and 6.8 K/9 in 78 IP.

  • Last start: No decision, 7 IP, 0 ER, 1 H, 1 BB, 6 K in 2-1 home loss against Pittsburgh Pirates Tuesday.
  • 2024 road stats: 4-4, 5.04 ERA (44 2/3 IP, 25 ER) in 8 starts

Taillon (3-2, 3.09 ERA) makes his 11th start. He has a 1.30 WHIP, 2.3 BB/9 and 6.5 K/9 in 55 1/3 IP.

  • Last start: No decision, 6 IP, 0 ER, 4 H, 1 BB, 5 K in 5-2 road loss to the Tampa Bay Rays Tuesday
  • 2024 home stats: 3-1, 3.42 ERA (26 1/3 IP, 10 ER) in 5 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Cardinals at Cubs odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:21 a.m. ET.

  • Moneyline (ML): Cardinals +116 (bet $100 to win $116) | Cubs -136 (bet $136 to win $100)
  • Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-166) | Cubs -1.5 (+138)
  • Over/Under (O/U): 11 (O: -110 | U: -110)

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Cardinals at Cubs picks and predictions

Prediction

Cubs 5, Cardinals 4

Moneyline

Despite their recent backslide, the Cubs are 13-9 straight up as a home favorite while the Cardinals are 12-16 as a road dog.

BET CUBS (-136).

Run line/Against the spread

As a favorite the Cubs are a paltry 8-22, I would rather pick them on the moneyline.

PASS.

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Over/Under

Both teams are on extensive Under streaks that cannot be sustained. The Cardinals haven’t hit the Over in 6 straight games while the Cubs Under streak is 8 games.

After a win the Cubs have the 4th best Over rate at 56.3% (18-14-1) so I expect some offense. But St. Louis in divisional games has the best Under record (12-5) and the current line is incredibly high for 2 teams that have struggled to score.

LEAN UNDER 11 (-110).

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