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The St. Louis Cardinals (34-34) and Chicago Cubs (33-37)) face off in the Saturday game of a 3-game weekend series. First pitch from Wrigley Field is set for 2:20 p.m. ET (FS1). Let’s analyze FanDuel Sportsbook’s lines around the Cardinals vs. Cubs odds and make our expert MLB picks and predictions for the best bets.
Season series: St. Louis leads 3-0
St. Louis picked up a 3-0 win in Friday’s series opener and covered as a +111 road underdog — the Under (7.5) cashed. The Cardinals broke a scoreless tie in the 8th with a solo HR from C Padro Pages and added 2 more runs in the 9th on RBIs from DH Ivan Herrera and OF Dylan Carlson to come away with the win, St. Louis’ 3rd in a row. SP Kyle Gibson was superb, yielding just 2 hits in 7 innings, while striking out 6.
Chicago, which finished with just 3 hits, has dropped back-to-back games and 6 of its last 8. The Cubs have only hit .212 and averaged 2.6 runs per game during the 8-game stretch. The pitching staff has given up at least 3 runs in each of the Cubs’ last 19 losses.
Cardinals at Cubs projected starters
RHP Andre Pallante vs. LHP Shota Imanaga
Pallante (2-2, 4.88 ERA) makes his 4th start and 13 appearance. He has a 1.58 WHIP, 4.5 BB/9 and 6.4 K/9 through 24 innings.
- Last start: Win, 5 IP, 0 ER, 3 H, 1 BB, 6 K in 5-1 home victory vs. Colorado Rockies Sunday
- 2024 road splits: 1-1, 4.00 ERA (9 IP, 4 ER), 11 H, 4 BB, 6 K in 5 outings (1 start)
- Career vs. Cubs: 0-1, 2.41 ERA (18 2/3 IP, 5 ER), 17 H, 9 BB, 9 K in 9 outings (2 starts)
Imanaga (6-1, 1.96 ERA) makes his 13th start. He has a 1.03 WHIP, 1.4 BB/9 and 9.4 K/9 through 69 innings.
- Last start: Win, 6 2/3 IP, 2 ER, 5 H, 1 BB, 7 K in 4-2 win at Cincinnati Reds Sunday
- 2024 home splits: 2-0, 1.31 ERA (34 1/3 IP, 5 ER), 0.84 WHIP, 10.0 K/9 in 6 starts
- Never faced Cardinals before (MLB debut: April 1, 2024)
Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.
Cardinals at Cubs odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 5:27 a.m. ET.
- Moneyline (ML): Cardinals +140 (bet $100 to win $140) | Cubs -166 (bet $166 to win $100)
- Run line (RL)/Against the spread (ATS): Cardinals +1.5 (-154) | Cubs -1.5 (+128)
- Over/Under (O/U): 8 (O: -106 | U: -114)
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Cardinals at Cubs picks and predictions
Prediction
Cardinals 4, Cubs 2
Moneyline
BET CARDINALS (+140).
St. Louis is the slightly hotter team, going 6-4 in its last 10; Chicago is 4-6 in its last 10. The Cardinals are also 4-1 in their last 5 overall and have won back-to-back road games.
The Cardinals are 4-0 in the last 4 head-to-head meetings vs. the Cubs dating back to last season.
Run line/Against the spread
PASS.
The Cardinals +1.5 (-154) should cover here, but their run line requires too much juice. Bet on the moneyline and/or Over/Under instead.
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Over/Under
BET UNDER 8 (-114).
The Under has hit in 5 consecutive games for St. Louis and is 7-3 in its last 10 overall. For Chicago, the Under is 7-0 in its last 7 games. The Under has also hit in back-to-back St. Louis-Chicago matchups and is 5-1 in the last 6 meetings.
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