The San Francisco Giants (11-14) open a 2-game series against the San Diego Padres (13-14) Saturday at Estadio Alfredo Harp Helú in Mexico City, Mexico. First pitch is scheduled for 6:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Padres odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting. The Padres recorded a 13-6 record against the Giants in 2022.
The Giants lost 6-0 to the St. Louis Cardinals Thursday. San Francisco had won 5 consecutive games before the loss.
The Padres fell 5-2 to the Chicago Cubs on Thursday. San Diego has tallied a 5-5 record in its last 10 games.
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Giants vs. Padres projected starters
LHP Sean Manaea vs. RHP Joe Musgrove
Manaea (0-1, 6.61 ERA) makes his 4th start and 6th appearance. He has a 1.29 WHIP, 3.9 BB/9 and 9.9 K/9 through 16 1/3 IP.
- Has notched 6 IP or more in only 1 of his 5 appearances (3 starts) this season
- Allowed at least 1 home run in 4 of his 5 outings
Musgrove (1-0, 5.40 ERA) makes his 2nd start. He has a 1.40 WHIP, 0.0 BB/9 and 10.8 K/9 through 5 IP.
- Allowed 3 ER on 7 H with 0 BB and 6 K across 5 IP in season debut victory over the Arizona Diamondbacks last Saturday
- Boasts a 4-3 record with a 3.15 ERA, 1.05 WHIP, and 9.1 K/9 in 12 career starts against the Giants
Giants vs. Padres odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:30 a.m. ET.
- Moneyline (ML): Giants +150 (bet $100 to win $150) | Padres -185 (bet $185 to win $100)
- Run line (RL)/Against the spread (ATS): Giants +1.5 (-110) | Padres -1.5 (-110)
- Over/Under (O/U): 15.5 (O: -110 | U: -110)
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Giants vs. Padres picks and predictions
Prediction
Padres 7, Giants 5
Moneyline
PASS.
Even with the Padres (-185) expected to secure the win on Saturday, taking them straight up isn’t advised at the current odds.
Run line/Against the spread
PADRES -1.5 (-110) is the pick in this NL West matchup in Mexico City. The Padres have the pitching advantage with Musgrove on the mound and Manaea on a short leash from the Giants to begin the season.
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Over/Under
UNDER 15.5 (-110) is how I’d wager on the total with it being such a high number. The elevation in Mexico City could lead to more runs in this showdown, but neither team has been hitting well enough to feel confident in 16-plus runs being scored.
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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