San Francisco Giants at Minnesota Twins odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Minnesota Twins odds and lines, with MLB expert picks, predictions and best bets.

The San Francisco Giants (24-24) conclude a 3-game series against the Minnesota Twins (25-24) on Wednesday at Target Field. First pitch is scheduled for 1:10 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Twins odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 2-0

The Giants defeated the Twins 4-3 on Tuesday to extend their win streak to 3 games. San Francisco is 7-3 in its last 10 games and is 6 games behind the Los Angeles Dodgers for 1st place in the NL West.

OF Byron Buxton hit his 10th home run of the season in the bottom of the 1st inning to grab an early lead in Tuesday’s loss. Minnesota is still 1st place in the AL Central despite going 4-6 in its last 10 games.

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Giants at Twins projected starters

RHP Anthony DeSclafani vs. RHP Joe Ryan

DeSclafani (3-3, 3.09 ERA) makes his 10th start. He has a 0.99 WHIP, 1.1 BB/9 and 6.7 K/9 through 55 1/3 IP.

  • After allowing a combined 9 ER in his first 6 starts, he’s allowed a combined 10 ER in his last 3 outings
  • Has pitched 6-plus innings in 6 of his 9 turns

Ryan (6-1, 2.25 ERA) makes his 10th start. He has a 0.89 WHIP, 1.3 BB/9 and 10.6 K/9 through 56 IP.

  • Has allowed more than 2 ER in just 2 starts
  • Has struck out 6-plus batters in 7 of his 9 turns

Giants at Twins odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:20 a.m. ET.

  • Moneyline (ML): Giants +135 (bet $100 to win $135) | Twins -160 (bet $160 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-160) | Twins -1.5 (+135)
  • Over/Under (O/U): 7.5 (O: +100 | U: -120)

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Giants at Twins picks and predictions

Prediction

Twins 4, Giants 2

Moneyline

Even with the Giants winning the first 2 games of the series, I’ll take the TWINS (-160) at home with Ryan on the mound. I wouldn’t wager on Minnesota’s moneyline at anything worse than -160 odds.

Run line/Against the spread

TWINS -1.5 (+135) has solid value with Ryan being one of the league’s top starting pitchers to begin the season. Minnesota has won by 3 or more runs in each of the 6 wins that Ryan has been credited with.

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Over/Under

UNDER 7.5 (-120) is how I’d bet on the run total with DeSclafani and Ryan taking the bump on Wednesday. There have been 5 or fewer runs scored in the first 2 games of the series.

The Giants are 4-0 to the Under in their last 4 interleague games and the Twins are 4-0 to the Under in their last 4 games overall.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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