San Francisco Giants at Chicago Cubs odds, picks and predictions

Analyzing Tuesday’s San Francisco Giants at Chicago Cubs odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (36-37) and Chicago Cubs (34-39) play the 2nd game of a 3-game set Tuesday. First pitch from Wrigley Field is scheduled for 8:05 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Giants vs. Cubs odds and make our expert MLB picks and predictions for the best bets.

Season series: Giants lead 1-0

The Giants won 7-6 as +103 underdogs in the series opener Monday as the Over (10) hit.

Giants 2B Thairo Estrada hit a go-ahead 3-run HR in the 9th inning, the Cubs’ 16th blown save this year (2nd-most in MLB). LF Heliot Ramos and C Patrick Bailey also hit HRs for San Francisco, which came back from a 3-run, 8th-inning deficit.

Giants at Cubs projected starters

RHP Logan Webb vs. LHP Justin Steele

Webb (6-5, 3.02 ERA) makes his 15th start. He has a 1.20 WHIP, 1.9 BB/9 and 7.6 K/9 in 92 1/3 innings.

  • Last start: Win, 6 IP, 3 ER, 7 H, 0 BB, 5 K in 5-3 home victory against Houston Astros Wednesday
  • 2024 road splits: 2-3, 4.06 ERA (44 1/3 IP, 20 ER), 1.35 WHIP, 8.9 K/9 in 8 starts

Steele (0-3, 3.22 ERA) makes his 10th start. He has a 1.09 WHIP, 2.3 BB/9 and 8.6 K/9 in 50 1/3 innings.

  • Last start: No-decision, 6 IP, 0 R, 3 H, 1 BB, 5 K in 3-2 road loss to Tampa Bay Rays Thursday
  • 2024 home splits: 0-2, 4.15 ERA (21 2/3 IP, 10 ER), 1.34 WHIP, 7.9 K/9 in 4 starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Cubs odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:35 a.m. ET.

  • Moneyline (ML): Giants -115 (bet $115 to win $100) | Cubs -105 (bet $105 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+140) | Cubs +1.5 (-165)
  • Over/Under (O/U): 9.5 (O: -110 | U: -110)

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Giants at Cubs picks and predictions

Prediction

Giants 3, Cubs 0

Moneyline

The Giants are 5-1 since May following a series-opening win, while the Cubs are coming off a heartbreaking home loss and dealing with a struggling bullpen.

LEAN GIANTS (-115).

Run line/Against the spread

While I like the Giants Tuesday, both teams have had their fair share of 1-run scores. I would PASS here and stick with the moneyline.

Over/Under

The Cubs have the best Under record after a loss this season at 23-13-2 (63.9%). Steele also hasn’t given up more than 1 run in each of his last 4 starts.

Webb hasn’t been as dominant lately, giving up 7 or more hits and 3-plus runs in 2 of his last 3 starts. However, the Cubs are batting just .214 with RISP, the 3rd-lowest mark in MLB, which will give the Giants plenty of opportunities to get out of a jam.

BET UNDER 9.5 (-110).

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