San Francisco Giants at Boston Red Sox odds, picks and predictions

Analyzing Thursday’s San Francisco Giants at Boston Red Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Boston Red Sox (18-13) welcome the San Francisco Giants (14-17) to Fenway Park Thursday for the finale of their 3-game series. First pitch is set for 1:35 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Red Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Red Sox lead 2-0

The Red Sox beat the Giants 6-2 Wednesday as -153 favorites. Boston has won 4 in a row, including a 17-0 victory over the Chicago Cubs Saturday. It has struggled at home, going just 7-8 straight up at Fenway Park. The Red Sox are 17-14 on the run line.

The Giants have lost 2 straight games and 4 of their last 6. San Fran’s offense has been in focus, as it has scored just 13 runs over its last 6 games. The Giants are 5-10 on the road, the 5th-worst win percentage in MLB. They are 13-18 on the run line.

Giants at Red Sox projected starters

LHP Kyle Harrison vs. RHP Josh Winckowski

Harrison (2-1, 4.09 ERA) makes his 7th start. He has a 1.24 WHIP, 1.4 BB/9 and 8.5 K/9 in 33 innings.

  • Last start: No-decision, 6 IP, 0 ER, 5 H, 0 BB, 7 K in 3-0 road win vs. Pittsburgh Pirates Friday
  • 2024 road splits: 2-1, 4.76 ERA, 17 IP, 9 ER (4 HR), 74 H, 4 BB, 11 K in 3 starts
  • Has never faced Boston before

Winckowski (1-1, 3.50 ERA) makes his 3rd start and 10th appearance. He has a 1.67 WHIP, 4.0 BB/9 and 9.5 K/9 in 18 innings.

  • Last start: No-decision, 3 IP, 0 ER, 3 H, 0 BB, 1 K in 17-0 home win vs. Chicago Cubs Saturday
  • 2024 home splits: 1-0, 1.08 ERA, 8 1/3 IP, 1 ER, 6 H (1 HR), 3 BB, 10 K in 1 start and 3 relief appearances
  • Career vs. San Francisco: 0-0, 3.38 ERA, 2 2/3 IP, 1.88 WHIP, 0 BB, 3 K in 2 relief appearances

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Giants at Red Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:16 a.m. ET.

  • Moneyline (ML): Giants -108 (bet $108 to win $100) | Red Sox -108 (bet $108 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants -1.5 (+140) | Red Sox +1.5 (-170)
  • Over/Under (O/U): 9.5 (O: -110 | U: -110)

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Giants at Red Sox picks and predictions

Prediction

Red Sox 5, Giants 2

Moneyline

BET RED SOX (-108).

Boston has been able to close out series that it has dominated well. It has won the 1st 2 games of 2 series (against the Oakland A’s and Pirates), and it won the 3rd both times. While he doesn’t pitch for typically over 3 innings, the Red Sox are 2-0 when Winskowski starts and have given up 1 combined run in those games.

The Giants, who have given up at least 4 runs in 3 of their last 4, have struggled to find offense. They are 1-1 straight up after losing the 1st 2 games of a series. There’s no reason to expect San Fran’s offense to bounce back Thursday.

Back RED SOX (-108).

Run line/Against the spread

PASS.

The Giants as run-line favorites are tough to sell, and they should be avoided here. The Red Sox as underdogs also aren’t worth the price, and they are better suited as a moneyline play.

Over/Under

BET UNDER 9.5 (-110).

The Giants offense has yet to bounce back, and they didn’t Wednesday either. San Fran has gone Under in 7 of its last 8 games and is 14-16-1 O/U on the season.

They have scored 3 or fewer runs in 6 straight games. Boston has gone Under in 5 of its last 10 and is 3-5-2 O/U in that span. Considering the recent trends for both teams, back UNDER 9.5 (-110).

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