San Francisco Giants at Boston Red Sox odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Boston Red Sox odds and lines, with MLB expert picks, predictions and best bets.

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The Boston Red Sox (17-13) welcome the San Francisco Giants (14-16) to Fenway Park for the 2nd game of a 3-game series Wednesday. First pitch is set for 7:10 p.m. ET. Let’s analyze FanDuel Sportsbook’s lines around the Giants vs. Red Sox odds and make our expert MLB picks and predictions for the best bets.

Season series: Red Sox lead 1-0

Boston continued its winning ways to open the series, beating the Giants 4-0 Tuesday. It has won 3 straight games, including a 17-0 beatdown of the Chicago Cubs Saturday. The Red Sox are 6-8 at home and 16-14 against the spread (ATS).

The Giants have been fickle over the last week, having traded off winning and losing over their last 6 games. They are 5-8 on the road. San Fran’s offense has been struggling as of late, scoring 3 or fewer runs in 5 straight games. San Fran is 13-17 ATS on the season.

Giants at Red Sox projected starters

TBD vs. RHP Kutter Crawford

According to reports, RHP Daulton Jefferies (0-1, 22.50 ERA) is expected to make his 2nd start, but the Giants have yet to confirm it. He allowed 5 earned runs on 9 hits and 0 walks with 1 K in 2 innings in his debut, a 13-4 loss at the San Diego Padres March 31.

  • 2024 stats with Triple-A Sacramento: 1-0, 3.44 ERA (18 1/3 IP, 7 ER), 1.04 WHIP in 2 starts and 2 relief appearances
  • Career road stats: 2-5, 7.34 ERA (30 2/3 IP, 25 ER), 1.63 WHIP in 7 starts and 2 relief appearances

Crawford (1-1, 1.35 ERA) makes his 7th start. He has a 1.11 WHIP, 3.0 BB/9 and 9.2 K/9 in 33 1/3 innings.

  • Last start: Loss, 6 IP, 3 ER, 10 H, 0 BB, 4 K in 7-1 home loss to Cubs Friday
  • Red Sox are 2-4 in his 6 starts
  • 2024 home splits: 0-1, 1.62 ERA, 16 2/3 IP, 3 ER, 14 H, 0 HR, 4 BB, 16 K in 3 starts

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Giants at Red Sox odds

Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:49 a.m. ET.

  • Moneyline (ML): Giants +102 (bet $100 to win $102) | Red Sox -120 (bet $120 to win $100)
  • Run line (RL)/Against the spread: Giants -1.5 (+162) | Red Sox +1.5 (-196)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

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Giants at Red Sox picks and predictions

Prediction

Red Sox 5, Giants 3

Moneyline

BET RED SOX (-120).

Crawford has been a strong option this season for the Red Sox, who have won 3 straight. Their offense has been incredibly consistent, scoring at least 4 runs in 5 of their last 6 games.

The same cannot be said of San Fran, and that difference in consistency offensively is the key here. The Giants have allowed at least 4 runs in 2 of their last 3 games and have failed to score more than 3 in 5 straight. The Giants are the 4th-worst team on the road at 5-9 as well.

Considering those trends, take RED SOX (-120).

Run line/Against the spread

PASS.

The Red Sox are far too expensive as run-line favorites, while the Giants aren’t worth the risk here as underdogs. Avoid a run-line play for either side.

Over/Under

LEAN UNDER 8.5 (-110).

The Giants have gone Under in 4 straight games and are 1-6 O/U in their last 7. Their offense has struggled, while their pitching has remained strong.

The Red Sox are 3-4-2 O/U in their last 9 games and 13-14-3 O/U on the season. They have allowed 0 runs in 2 of their last 3 games and 3 of their last 6. Take UNDER 8.5 (-110).

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