San Francisco Giants at Arizona Diamondbacks odds, picks and predictions

Analyzing Wednesday’s San Francisco Giants at Arizona Diamondbacks odds and lines, with MLB expert picks, predictions and best bets.

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The San Francisco Giants (79-79) and Arizona Diamondbacks (87-71) close out their 3-game series and their season series Wednesday. First pitch from Chase Field is at 9:40 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s MLB odds around the Giants vs. Diamondbacks odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 6-6

The Giants have won the 1st 2 games of the series (6-3 and 11-0) and have a 5-game winning streak. They shut out Arizona on Tuesday night behind starter Logan Webb. (6 IP, 0 ER, 4 H, 1 BB, 4 K).

The Diamondbacks have lost 3 in a row and hold a half-game lead over the Atlanta Braves for the final NL Wild Card berth. They are tied in the loss column with them. They are a half-game behind the New York Mets for the 2nd Wild Card spot.

Giants at Diamondbacks projected starters

RHP Mason Black vs. RHP Zac Gallen

Black (1-4, 5.88 ERA) makes his 8th start and 9th career appearance. He has a 1.52 WHIP, 2.7 BB/9 and 7.5 K/9 in 33 2/3 IP.

  • Last start: Win, 5 2/3 IP, 0 R, 4 H, 1 BB, 4 K in 2-1 road win over Kansas City Royals Friday
  • Facing Arizona for 1st time

Gallen (13-6, 3.74 ERA) makes his 28th start. He has a 1.29 WHIP, 3.3 BB/9 and 9.2 K/9 in 142 IP.

  • Last start: Win, 5 IP, 4 ER, 7 H, 1 BB, 5 K in 7-4 road win over Milwaukee Brewers Friday
  • Is 3-0 with 3.00 ERA in 4 September starts
  • Vs. the Giants: Is 1-1 with 4.09 ERA in 2 starts in 2024 and 5-5 with 4.15 ERA in 15 career starts

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Giants at Diamondbacks odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list of MLB odds. Lines last updated at 9:21 a.m. ET.

  • Moneyline (ML): Giants +185 (bet $100 to win $185) | Diamondbacks -225 (bet $225 to win $100)
  • Run line (RL)/Against the spread (ATS): Giants +1.5 (-110) |Diamondbacks -1.5 (-110)
  • Over/Under (O/U): 8.5 (O: -110 | U: -110)

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Giants at Diamondbacks picks and predictions

Prediction

Diamondbacks 7, Giants 3

Moneyline

The Diamondbacks have not been swept in a series at home yet this season. And while the Giants are 7-1 on their current road trip, Black has allowed 4 or more runs in 4 of his 8 appearances this season.

Arizona has won Gallen’s last 4 starts and should win, but don’t bet the moneyline at -225

PASS.

Run line/Against the spread

Sixteen of the Diamondbacks’ last 18 wins have been by 2 or more runs. Five of the last 6 wins by Arizona when Gallen pitches have been by 2 or more runs. Five of their 6 wins over the Giants this season have been by 2 or more runs.

BET DIAMONDBACKS -1.5 (-110).

Over/Under

Eight of their 12 meetings this season have had totals of more than 8 runs and 6 of the Diamondbacks’ last 8 games have had 9 or more total runs.

BET OVER 8.5 (-110).

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