The San Francisco 49ers (9-4) meet the Seattle Seahawks (7-6) for a Thursday Night Football matchup in Week 15. Kickoff at Lumen Field in Seattle is scheduled for 8:15 p.m. ET (Prime Video). Below, we analyze Tipico Sportsbook’s lines around the 49ers vs. Seahawks odds, and make our expert NFL picks and predictions.
The 49ers (-3.5) throttled the visiting Tampa Bay Buccaneers by a 35-7 score, but the victory came with a huge price. WR Deebo Samuel suffered ankle and knee injuries in the 1st half, and is unlikely to play with the short turnaround.
QB Brock Purdy outdueled future Hall of Famer QB Tom Brady, and it wasn’t even close actually. Purdy tossed 2 TDs while running for another, and RB Christian McCaffrey totaled 153 total scrimmage yards with 2 scores.
The Seahawks are coming off a disappointing home loss to the Carolina Panthers 30-24 as 4-point favorites. As such, Seattle has failed to cover in its last 4 games, while winning just once during the span.
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49ers at Seahawks odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 9:56 p.m. ET.
- Moneyline (ML): 49ers -180 (bet $180 to win $100) | Seahawks +155 (bet $100 to win $155)
- Against the spread: 49ers -3.5 (-104) | Seahawks +3.5 (-116)
- Over/Under (O/U): 43 (O: -107 | U: -113)
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49ers at Seahawks key injuries
49ers
- DT Arik Armstead (foot, ankle) questionable
- QB Jimmy Garoppolo (foot) out
- RB Christian McCaffrey (knee) questionable
- QB Brock Purdy (oblique, rib) questionable
- WR Deebo Samuel (ankle, knee) doubtful
Seahawks
- RB DeeJay Dallas (ankle) questionable
- S Quandre Diggs (shoulder) questionable
- S Ryan Neal (knee) questionable
- RB Kenneth Walker III (ankle) questionable
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49ers at Seahawks picks and predictions
Prediction
49ers 25, Seahawks 16
Moneyline
The 49ERS (-180) are a little on the expensive side here, especially on the road. However, the Seahawks (+155) were abysmal last time out against the Panthers, while San Francisco steamrolled Tampa Bay. Momentum is definitely on the side of the visitors, and the 49ers and their coaching staff appear to have confidence in Purdy.
There is risk, as the offense should look a little different with Deebo on the shelf, but with weapons like McCaffrey and George Kittle, Frisco still has plenty of talented skill-position players to get it done.
Against the spread
Play the 49ERS -3.5 (-104), even though 3 and a hook is never an attractive line when playing a favorite.
Still, the 49ers had no problem dusting the Buccaneers and covering by a mile, while the Seahawks suffered the damaging home loss as a favorite last week.
Seattle has issues on offense, missing key skill position players, particularly at tailback, and the ones who will be up are a little nicked at the moment.
Over/Under
UNDER 43 (-113) is a rather high number given the fact San Francisco rolls in with the league’s No. 1 defense in terms of total yards allowed (286.8), rushing yards allowed (75.1) and points allowed (15.2).
Yes, Seattle’s defense has struggled, but the Niners are going to gain yardage in short chunks with Deebo on the shelf.
The Under is 9-3 in San Francisco’s last 12 games against winning teams, while cashing at a 4-0 clip in the last 4 road outings against teams with a winning home record.
While the Over has been the dominant trend for the Seahawks, including the damaging Week 14 loss, the Under is 6-2 in its last 8 TNF apperances, and 10-4 in the previous 14 against teams with a winning overall record.
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