The San Francisco 49ers (1-1) are on the road in Week 3 to face the Denver Broncos (1-1) for a Sunday Night Football matchup between two familiar foes — QBs Jimmy Garoppolo and Russell Wilson. Kickoff from Empower Field at Mile High is set for 8:20 p.m. ET (NBC). Below, we analyze Tipico Sportsbook‘s lines around the 49ers vs. Broncos odds, and make our expert NFL picks and predictions.
The 49ers bounced back from their season-opening loss to the Chicago Bears with a 27-7 win over the Seattle Seahawks in Week 2. They lost QB Trey Lance for the season with a broken ankle, so Garoppolo, who led the Niners to the NFC title game last season, returns to the starting lineup.
The Broncos lost17-16 to the Seahawks in Week 1. Denver had opportunities to win its opener but missed a potential game-winning 65-yard field goal and fumbled twice at the goal line. However, the Broncos bounced back in Week 2 as they defeated the Houston Texans 16-9. Their defense has held both opponents to under 260 yards of offense each week.
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49ers at Broncos odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:10 a.m. ET.
- Money line (ML): 49ers -120 (bet $120 to win $100) | Broncos +102 (bet $100 to win $102)
- Against the spread (ATS): 49ers -1.5 (-112) | Broncos +1.5 (-108)
- Over/Under (O/U): 44.5 (O: -105 | U: -115)
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49ers at Broncos key injuries
49ers
- DL Arik Armstead (foot) questionable
- OL Dane Brunskill (hamstring) out
- RB Tyrion Davis-Price (ankle) out
- OL Colton McKivitz (ankle) questionable
Broncos
- WR KJ Hamler (knee, hip) questionable
- WR Jerry Jeudy (rib, shoulder) questionable
- LB Josh Jewell (calf, knee) questionable
- DL Dre’Mont Jones (neck) questionable
- OL Quinn Meinerz (hamstring) questionable
- CB Pat Surtain II (shoulder) questionable
- OL Billy Turner (knee) questionable
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49ers at Broncos picks and predictions
Prediction
Broncos 20, 49ers 17
Money line
The Broncos may be missing a lot of players but Wilson is 16-4 in his career against the 49ers.
Neither team has allowed an opponent to record 260 yards of offense, so this may come down to which team avoids turning over the ball.
Garoppolo will give it up at least once and Wilson will lead a game-winning drive.
Take the BRONCOS (+102).
Against the spread
The Broncos have not yet covered the spread in either game this season. The 49ers are 1-1 ATS.
With a 1.5-point spread, you are basically picking the winner like on the money line.
Denver has had 2 close games but this is the week they finally break through to get the win.
Take the BRONCOS +1.5 (-108).
Over/Under
Neither team has had a game hit the Over so far. The 49ers have had games of 29 and 34 total points. The Broncos’ 2 games finished with 33 and 25 points.
Both teams have stingy defenses. The Broncos have not yet had the big offensive boost they were hoping for with Wilson under center.
Take UNDER 44.5 (-115).
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