The Arizona Cardinals (8-6) take on the San Francisco 49ers (5-9) in one of three Saturday games in Week 16. Kickoff is Saturday afternoon at 4:30 p.m. ET at State Farm Stadium in Glendale, AZ.
Below, we preview the 49ers-Cardinals betting odds and lines and make our NFL picks and predictions.
49ers at Cardinals: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 1:40 a.m. ET.
- Money line: 49ers +200 (bet $100 to win $200) | Cardinals -250 (bet $250 to win $100)
- Against the spread/ATS: 49ers +5 (-110) | Cardinals -5 (-110)
- Over/Under: 48.5 (O: -110 | U: -110)
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49ers at Cardinals: Game notes
- San Francisco has lost three games in a row, six out of seven and has been eliminated from postseason contention. The Cardinals have won two in a row and can potentially clinch a playoff berth this weekend.
- Cardinals QB Kyler Murray is coming off a career-high 406 passing yards in Week 15 with three passing touchdowns and a rushing touchdown. He was named NFC Offensive Player of the Week for the third time this season.
- Arizona has collected 14 sacks in the last two weeks.
- 49ers QB C.J. Beathard is making his first start of 2020 in place of the injured Jimmy Garoppolo and Nick Mullens. Beathard is 1-9 in his career as a starter.
- In the Cardinals’ 24-20 season-opening win over the 49ers, QR DeAndre Hopkins had a career-high 14 receptions for 151 yards.
49ers at Cardinals: Key injuries
49ers
- QB Nick Mullens (elbow) out
- RB Raheem Mostert (ankle) out
- WR Deebo Samuel (hamstring) out
- CB Richard Sherman (calf) out
- S Jimmie Ward (concussion) questionable
- CB Emmanuel Moseley (hamstring) questionable
Cardinals
- LB Dennis Gardeck (knee) out
- RB Chase Edmonds (knee, ankle) questionable
- WR Larry Fitzgerald (groin) questionable
- TE Dan Arnold (back) questionable
- LB Haason Reddick (shoulder) questionable
49ers at Cardinals: Odds, betting lines, predictions and picks
Prediction
Cardinals 31, 49ers 17
Money line (?)
Arizona is playing good football again, winning two in a row after losing three straight. San Francisco has lost six of seven and is down to its third-string quarterback and does not have its top running back, receiver, pass rusher, cornerback and safety.
Beathard is making his fifth appearance against the Cardinals in his career. He has never beaten them and Arizona needs to win to stay in control of the No. 7 seed in the NFC. Take the CARDINALS (-250).
Against the spread (?)
In addition to losing six of seven games, the 49ers have failed to cover in any of those six losses. They are 5-9 ATS this season. Arizona is 7-7 ATS but has won and covered in their last two games after failing to cover the spread in five straight. They should be able to move the ball and score points on a depleted 49ers defense and maintain their playoff chances.
Take the CARDINALS -5 (-110).
Over/Under (?)
The Cardinals’ offense seems to be back on track. Their games have gone Over only five times this season but those five times have been in the last eight games. San Francisco’s games have gone Under in three of five. Arizona’s offense will be fine, but with Beathard at QB without the 49ers’ top offensive players, they will struggle.
Take UNDER 48.5 POINTS (-110).
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Also see:
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3 San Francisco 49ers selected to Pro Bowl (Niners Wire)
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