San Diego Padres at St. Louis Cardinals odds, picks and predictions

Analyzing Tuesday’s San Diego Padres at St. Louis Cardinals odds and lines, with MLB expert picks, predictions and best bets.

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The San Diego Padres (75-58) and St. Louis Cardinals (65-66) play the 2nd game of a 4-game series Tuesday at Busch Stadium at 7:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Cardinals odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 2-2

The Padres rolled to a 7-4 victory Monday as RHP Kyle Gibson never really gave his squad a chance. He allowed 7 ER in 4 1/3 IP as 3B Manny Machado touched seats with his 21st HR. OF Jackson Merrill had 2 hits and 3 RBIs.

SS Masyn Winn and OF Alec Burleson went a combined 6-for-11 Monday at the top of the order, but 3-4-5 went a combined 0-for-12. That’s the Cardinals season in a nutshell – get runners on, don’t score and watch the traffic go around the bases on defense.

Padres at Cardinals projected starters

RHP Dylan Cease vs. RHP Miles Mikolas

Cease (12-10, 3.43 ERA) makes his 28th start. He has a 1.05 WHIP, 3.0 BB/9 and 11.2 K/9 in 154 2/3 IP.

  • Last start: Loss, 6 1/3 IP, 2 ER, 9 H, 1 BB, 7 K Thursday against New York Mets
  • 1 career start vs. St. Louis: No-decision, 6 IP, 5 ER, 11 H, 0 BB, 8 K on July 7, 2023

Mikolas (8-10, 5.19 ERA) makes his 27th start. He has a 1.26 WHIP, 1.4 BB/9 and 6.2 K/9 in 144 IP.

  • Last start: No-decision, 6 IP, 0 ER, 2 H, 1 BB, 3 K Thursday against Milwaukee Brewers
  • Last 5 regular season starts vs. Padres: 2-1, 2.43 ERA, 1.18 WHIP, 19 K in 29 2/3 IP

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Padres at Cardinals odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 1:59 p.m. ET.

  • Moneyline (ML): Padres -145 (bet $145 to win $100) | Cardinals +120 (bet $100 to win $120)
  • Run line (RL)/Against the spread (ATS): Padres -1.5 (+125) | Cardinals +1.5 (-155)
  • Over/Under (O/U): 8 (O: -105 | U: -115)

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Padres at Cardinals picks and predictions

Prediction

Padres 5, Cardinals 2

Moneyline

The Padres are moderate favorites here. Frankly, I think they’re a bargain at -145. This Cardinals team’s starting pitching has imploded, and they’re one of the worst teams with runners in scoring position in baseball.

This offense struggled to score against Randy freakin Vasquez Monday night. Cease has been more hittable of late, but I think he dominates.

Take the PADRES -145.

Run line/Against the spread

I repeat, Cease will dominate Tuesday night. He fanned 8 Cards in a 5-ER outing against them last year, and I will take the plus-money for DYLAN CEASE OVER 6.5 STRIKEOUTS (+125).

Over/Under

The Over snuck by Monday, but it took a putrid pitching showing from the Cards to do it. Basically, do you think the Padres can score 6-7 runs to cash an Over Tuesday? Sure, they could, but that’s tough to bank on. The Cards are 3-7 O/U in their last 10, and the Over is 3-5-2 in the last 10 matchups between these teams.

LEAN UNDER 8 (-115).

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