San Diego Padres at San Francisco Giants odds, picks and predictions

Analyzing Saturday’s San Diego Padres at San Francisco Giants odds and lines, with MLB expert picks and predictions.

The San Diego Padres (25-14) and San Francisco Giants (22-16) meet Saturday at 4:10 p.m. ET in the continuation of a 3-game series at Oracle Park. Let’s analyze Tipico Sportsbook‘s lines around the Padres vs. Giants odds with MLB picks and predictions.

Season series: tied 2-2.

The Padres won Friday’s series opener 8-7 in 10 innings. San Diego heads into this Saturday matinee having won 4 of its last 5.

Friday’s game snapped a 5-game home win streak for the Giants. San Francisco pitching was on fire early in the season with a 2.32 ERA through April 27 but has logged a 5.66 mark since.

Padres at Giants projected starters

RHP Joe Musgrove vs. LHP Carlos Rodon

Musgrove (4-0, 2.20 ERA) has logged a 0.93 WHIP, 1.2 BB/9 and 9.4 K/9 through 45 IP across 7 starts.

  • Clocked a 6.08 ERA while allowing an .898 OPS in 5 starts vs. San Francisco last season.
  • Averages 92 pitchers per start but has made 108 and 99 over his last 2 turns.

Rodon (4-2, 3.49 ERA) is tabbed for his 8th start. He has a 1.11 WHIP, 3.0 BB/9 and 13.0 K/9 through 38 2/3 IP.

  • Toted a 1.80 ERA into his last start but allowed 8 runs on 10 hits in 3 2/3 IP vs. the St. Louis Cardinals Sunday.
  • Owns a 2.12 ERA and 1.06 WHIP in 17 IP at home.

Padres at Giants odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated 8:11 a.m. ET.

  • Money line: Padres +115 (bet $100 to win $115) | Giants -140 (bet $140 to win $100)
  • Run line (RL): Padres +1.5 (-190) | Giants -1.5 (+155)
  • Over/Under (O/U): 6.5 (O: -125 | U: +100)

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Padres at Giants picks and predictions

Prediction

Giants 4, Padres 2

Money line

Expect a bounce-back for Rodon after a couple of high-pitch efforts likely led to the rocky outing in his last turn. His overall numbers have some play because he’s pitched through a .345 batting average on balls in play.

The Giants’ 5.16 runs per game rank second in MLB, and the home nine has had its way in games against Musgrove. S.F. has been okay versus righties so far, but that’s with a .248 BABIP.

Take SAN FRANCISCO (-140).

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Run line/Against the spread

The Giants are 10-5 in games decided by 5 runs or more. BACK SAN FRANCISCO -1.5 (+155).

Over/Under

Crisscrossing signals here: PASS.

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