San Diego Padres at Pittsburgh Pirates odds, picks and prediction

Analyzing Wednesday’s San Diego Padres at Pittsburgh Pirates odds and lines, with MLB picks and predictions.

The San Diego Padres (8-4) and Pittsburgh Pirates (4-7) play the third contest of their four-game series at PNC Park at 6:35 p.m. ET Wednesday. Let’s analyze BetMGM Sportsbook‘s lines around the Padres vs. Pirates odds with MLB picks and predictions.

RHP Joe Musgrove is the projected starting pitcher for the Padres. In 10 starts over the last two seasons, he is 3-5 with a 2.80 ERA, 0.95 WHIP, 12.0 K/9 and 2.6 BB/9 over 54 2/3 IP. The 28-year-old right-hander has exhibited an uptick in velocity while tossing 15 scoreless frames thus far in 2021. He’s coming off a no-hitter at the Texas Rangers April 9.

LHP Tyler Anderson draws Wednesday’s turn for the Pirates. In 15 appearances over 2020-21, Anderson is 4-5 with a 4.50 ERA, 1.43 WHIP, 6.8 K/9 and 3.5 BB/9 over 70 IP. The Pittsburgh lefty is coming off back-to-back losses to the Chicago Cubs with 6 total runs allowed over 10 1/3 innings.

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Padres at Pirates odds, lines, picks and prediction

MLB odds courtesy of BetMGM; access USA TODAY Sports for a full list. Odds last updated at 3:05 p.m. ET.

  • Money line: Padres -200 (bet $200 to win $100) | Pirates +170 (bet $100 to win $170)
  • Against the spread/ATS: Padres -1.5 (-120) | Pirates +1.5 (+100)
  • Over/Under: 8 (O: -105 | U: -115)

Prediction

Padres 6, Pirates 4

Money line (ML)

The Padres are tough on lefty pitching and have the better bullpen. The Friars are a decent value play up to -190.

PASS OTHERWISE.

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Run line/Against the spread (ATS)

TAKE PADRES -1.5 (-120).

Look for San Diego to play its platoon-bullpen-offensive advantage into a multi-run win in a higher scoring game than what’s forecasted by the 8-run total.

Over/Under (O/U)

The Over had a slight lean and barely hit on a line of 7.5 Monday. Tuesday’s game figured as a solid Over (again on a 7.5), and the Pirates won 8-4. The weather report calls for a hitter’s breeze out to left in Wednesday’s game.

Musgrove threw 112 pitches in his no-no and has a checkered history — though one with bigger misfires than hits — in starts after 95-plus pitches. Anderson — a fly-ball pitcher — has coughed up 3 HR in 10 IP. Current SD batters own a .907 OPS against him.

The Padres also own an early .309/.406/.506 slash line against southpaws.

TAKE THE OVER 8 (-105).

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