2. Edgerrin James, RB – 1999-2005 Indianapolis Colts, 2006-08 Arizona Cardinals, 2009 Seattle Seahawks
The NFL’s rushing leader in 1999 and 2000, James is one of the best all-around backs. He rushed for 12,246 yards and had 433 receptions. He also was a member of the 2000s All-Decade team.