Pittsburgh Pirates at San Diego Padres odds, picks and predictions

Analyzing Friday’s Pittsburgh Pirates at San Diego Padres odds and lines, with MLB expert picks and predictions.

The Pittsburgh Pirates (18-25) open a 3-game road series against the San Diego Padres (28-16) Friday. First pitch is 9:40 p.m. ET at Petco Park. Let’s analyze Tipico Sportsbook‘s lines around the Pirates vs. Padres nickname odds with MLB picks and predictions.

The Padres lead the season series 2-1.

The Pirates were off Thursday and are coming off a 2-1 series win over the Colorado Rockies. However, they have lost 6 of their last 9 games.

The Padres lost 2 of 3 contests against the Milwaukee Brewers in their last series but have won 7 of their last 10 games. They have been a very average 11-9 at Petco Park.

Pirates at Padres projected starters

LHP Jose Quintana vs. LHP Sean Manaea

Quintana (1-2, 2.43 ERA) makes his 9th start. He has a 1.18 WHIP, 3.3 BB/9 and 7.5 K/9 through 40 2/3 IP.

  • Had his shortest outing in his last start as he allowed 5 runs (2 earned) on 7 hits over 3 2/3 innings in a 5-4 loss vs. the St. Louis Cardinals.
  • Has allowed 2 or fewer runs in 6 of his 8 starts this season.

Manaea (2-3, 4.04 ERA) makes his 9th start. He has a 1.12 WHIP, 2.9 BB/9 and 10.1 K/9 through 49 IP.

  • Took a no-decision in a 7-6 loss at the Pirates April 30 with 6 2/3 IP, 3 ER, 5 H, 3 BB and 6 K.
  • Has allowed 3 or more runs in each of his last 5 outings.

Pirates at Padres odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:55 p.m. ET.

  • Money line (ML): Pirates +175 (bet $100 to win $175) | Padres -220 (bet $220 to win $100)
  • Run line (RL)/Against the spread (ATS): Pirates +1.5 (-130) | Padres -1.5 (+105)
  • Over/Under (O/U): 7.5 (O: +112 | U: -140)

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Pirates at Padres picks and predictions

Prediction

Pirates 5, Padres 4

Money line

Manaea has been very hittable in recent weeks, while Quintana has been fantastic this season.

If there is a game the Pirates can steal in this series, it would be Friday’s contest.

Pittsburgh is 5-3 with Quintana on the mound and won 3 of his last 4 outings.

The Padres have lost 4 of Manaea’s last 5 starts.

I like the upset tonight.

Take the PIRATES (+175).

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Run line/Against the spread

The Pirates are 20-23 ATS on the season. They have covered the spread only 3 times in their last 10 games.

The Padres are 24-20 ATS overall this season but are the league’s second-worst team against the spread at home at 6-14 ATS.

The money line is the best value for the Pirates but if you aren’t confident enough in an outright win for Pittsburgh, the line here is still worth it.

Take the PIRATES +1.5 (-130).

Over/Under

Manaea’s last 5 starts have all had 8 or more runs.

Four of the Pirates’ last 6 games have had more than 7 runs.

Two of the 3 games the two teams played in Pittsburgh had more than 8 runs.

Take OVER 7.5 (+112).

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