The No. 25 Pittsburgh Panthers (6-2, 3-1 ACC) and Duke Blue Devils (3-5, 0-4) clash in a Saturday noon ET game at Wallace Wade Stadium in Durham, N.C. Below, we look at the Pittsburgh vs. Duke odds and lines, and make our expert college football picks, predictions and bets.
Rankings courtesy of the AFCA Coaches Poll powered by USA TODAY Sports.
Pittsburgh is coming off a 38-34 loss to Miami (Fla.). The Panthers allowed several big plays early and couldn’t rally from a 21-7 deficit. The setback on home turf snapped a four-game win streak.
Duke has struggled mightily since opening the season with three victories over four games in the month of September. The Blue Devils lost, 45-7, at No. 13 Wake Forest last week, and they have been outscored, 93-7, over their last two games.
The Panthers have won nine of the past 10 matchups in this series, including five in a row. The last meeting was a 33-30 Pitt victory in Durham in 2019.
Pittsburgh at Duke odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 8:00 a.m. ET.
- Money line: Pittsburgh -1100 (bet $1,100 to win $100) | Duke +650 (bet $100 to win $650)
- Against the spread (ATS): Pittsburgh -21.5 (-107) | Duke +21.5 (-115)
- Over/Under (O/U): 64.5 (O: -115 | U: -107)
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Pittsburgh at Duke odds, lines, picks and predictions
Prediction
Pittsburgh 38, Duke 20
Money line
PASS after a significant price drop on Duke. There is some contrarian profit to be made on the home side and the points.
Against the spread
Duke ranks 92nd in the nation in scoring but 26th in total yards. Turnovers (DU is a minus-4) have hurt, but the Blue Devils do a decent job in staying on schedule. Duke’s offense has been awful over its last two games, but the Devils’ passing game has shown an effectiveness that could play for some sneaky upside against Pitt.
The Panthers could be caught flat-footed in a noon start and perhaps looking forward to a game against North Carolina.
TAKE THE BLUE DEVILS +21.5 (-115).
Over/Under
61.5 is the highest Over in the last seven meetings between Pitt and Duke.
BACK THE UNDER 64.5 (-107) on what figures to be a chilly and somewhat breezy afternoon in Durham. The better offense (Pitt) has red-zone numbers perhaps too amped up from the way it moves down the field in general.
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