It had been a while since Notre Dame lost to an inferior opponent at Notre Dame Stadium before Marshall came to South Bend in the second week of the 2022 season and threw the Irish around en route to a 26-21 upset victory. Based on the way Marshall played as the game went on they only gained more control so I hesitate to really call them an inferior opponent but you catch the drift.
From 1988-1989 Notre Dame didn’t lose a single home game and made it all the way until 1990 when the top-ranked Irish fell as a significant favorite to a Stanford team that was unranked. That’s where our list of the worst home losses in recent Notre Dame memory begins.