New York Jets at Buffalo Bills odds, picks and prediction

Analyzing Sunday’s New York Jets at Buffalo Bills odds and lines, with expert NFL picks, predictions and best bets.

The New York Jets‘ (4-12) miserable 2021 season will come to a close on Sunday when they visit the playoff-bound Buffalo Bills (10-6). Kickoff for this AFC East tilt from Highmark Stadium will be at 4:25 p.m. ET. Below, we look at the Jets vs. Bills odds and lines, and make our best NFL picks, predictions and bets.

The Jets are coming off a heartbreaking 28-24 loss to the Tampa Bay Buccaneers in Week 17. QB Tom Brady threw a touchdown pass in the final seconds to give the Bucs the win, preventing the Jets from winning their second straight game. The Jets are just 3-7 in their last 10 games, although they have scored at least 24 points in each of their last three.

The Bills are riding a three-game win streak into this one, taking all three of those games by at least 12 points. They’re now in control of the AFC East after beating the New England Patriots two weeks ago, putting themselves in a position to host a playoff game in the wild-card round with a victory Sunday.

Jets at Bills odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:53 a.m. ET.

  • Money line: Jets +850 (bet $100 to win $850) | Bills -1800 (bet $1,800 to win $100)
  • Against the spread (ATS): +16.5 (-112) | Bills -16.5 (-108)
  • Over/Under (O/U): 40.5 (O: -112 | U: -108)

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Jets at Bills key injuries

Jets

  • WR Braxton Berrios (thigh) out

Bills

  • DE Efe Obada (ankle) out
  • WR Emmanuel Sanders (knee) doubtful

Let’s Make This Interesting

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Jets at Bills odds, lines, predictions and picks

Prediction

Bills 31, Jets 17

Money line

The Bills won 45-17 the last time these teams met. It was a completely dominant performance from a Buffalo team that was favored by 13.5 points in that one. However, the Bills have been susceptible to letdowns as big favorites with outright losses to the Jacksonville Jaguars as 14.5-point favorites and the Indianapolis Colts as 7-point favorites.

I expect the Bills to win this one but it’s not worth a wager at -1800. PASS.

Against the spread

The Jets have played surprisingly well in the last three weeks, keeping things close with the Miami Dolphins and Tampa Bay, and beating Jacksonville by 5 points. They’re 3-0 ATS in their last three games and have built some momentum.

I like the JETS +16.5 (-112) getting the points and covering Sunday.

Over/Under

The Jets have played much better offensively in their last 10 games, and the total has gone over seven times in that span as a result. The Bills have remained steady and scored at least 27 points in five of their last six games, with the only exception being a windy 14-10 loss to the Patriots.

Bet the OVER 40.5 (-112) in this game. The Bills could hit that number themselves.

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