New Orleans Saints at New England Patriots odds, picks and prediction

Analyzing the New Orleans Saints at New England Patriots Week 3 odds and lines, with expert NFL picks, predictions and best bets.

The New Orleans Saints (1-1) are on the road in Week 3 to take on the New England Patriots (1-1). Kickoff is scheduled for 1 p.m. ET Sunday at Gillette Stadium. Below, we look at the Saints at Patriots odds and lines, and make our best NFL picks, predictions and bets.

The Saints started the season with a 38-3 shellacking of the Green Bay Packers but were unable to maintain that level of play as they lost in Week 2 to the Carolina Panthers 26-7. QB Jameis Winston threw 5 touchdown passes in the season opener but none in Week 2 and he was intercepted twice.

The Patriots lost 17-16 in Week 1 to the Miami Dolphins. New England dominated that game but lost because, in four trips to the red zone, they scored only one touchdown and turned the ball over once. They followed it up with a 25-6 win over the New York Jets but struggled offensively in that game.

Saints at Patriots odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 11:17 a.m. ET.

  • Money line: Saints +122 (bet $100 to win $122) | Patriots -150 (bet $150 to win $100)
  • Against the spread (ATS): Saints +2.5 (+100) | Patriots -2.5 (-125)
  • Over/Under (O/U): 42.5 (O: -108 | U: -112)

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Saints at Patriots key injuries

Saints

  • Erik McCoy (calf) questionable
  • CB Marshon Lattimore (hand) questionable

Patriots

  • LB Matt Judon (knee) questionable
  • RB Damien Harris (finger) questionable
  • OT Trent Brown (calf) questionable

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Saints at Patriots odds, lines, predictions and picks

Prediction

Saints 20, Patriots 17

Money line

We’ve seen a completely dominant Saints and a completely dominated Saints team through the first two weeks. They should be able to give Patriots rookie QB Mac Jones some problems even though they struggled defensively in Week 2. However, if Lattimore can’t play, it does change things.

Both teams are strong defensively, so it comes down to quarterback play. Who do you trust more at this point? For me, it’s Winston, for now.

That’s why I lean SAINTS (+122).

Against the spread

Both teams are 1-1 ATS this season so far. The Patriots have the best ATS home record since 2015 at 34-19-3 ATS. However, most of that was with Tom Brady at quarterback.

Conversely, at 32-16-1 ATS, the Saints have fared the best against the spread on the road since 2015.

Expecting an outright Saints win, take the SAINTS +2.5 (+100).

Over/Under

This is where it seems like easy money.

Both teams are 0-2 O/U to the start the year. The Patriots have not allowed more than 17 points in a game, and the Saints have allowed only 29 points in their two games.

Both are in the top six in points allowed.

With two strong defenses, expect a low-scoring affair. Take UNDER 42.5 (-112).

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