New England Patriots at Cleveland Browns odds, picks and predictions

Analyzing Sunday’s New England Patriots at Cleveland Browns odds and lines, with expert NFL picks, predictions and best bets.

The New England Patriots (2-3) and the Cleveland Browns (2-3) meet Sunday at First Energy Stadium in Cleveland. Kickoff is scheduled for 1 p.m. ET (CBS). Below, we analyze Tipico Sportsbook‘s lines around the Patriots vs. Browns odds, and make our expert NFL picks and predictions.

The Patriots snapped a 2-game slide in a big way, topping the previously high-octane Detroit Lions by a 29-0 count in Foxborough in Week 5. After opening the season 0-2-1 ATS, the Pats have covered 2 in a row.

The Browns have lost 3 games, including a 1-2 showing at home. Although, those 3 setbacks are by a combined 6 points. Cleveland needs to figure out how to close out one-score games. So far, 4 of the team’s 5 games have been decided by 3 or fewer points.

Also seeAll Week 6 odds and lines

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Patriots at Browns odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 6:22 p.m. ET.

  • Moneyline (ML): Patriots +117 (bet $100 to win $117) | Browns -140 (bet $140 to win $100)
  • Against the spread (ATS): Patriots +2.5 (-103) | Browns -2.5 (-117)
  • Over/Under (O/U): 43.5 (O: -108 | U: -112)

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Patriots at Browns key injuries

Patriots

  • WR Nelson Agholor (hamstring) out
  • DL Christian Barmore (knee) questionable
  • DL Lawrence Guy (shoulder) questionable
  • RB Damien Harris (hamstring) questionable
  • CB Jonathan Jones (ankle) out
  • QB Mac Jones (ankle) questionable
  • LB Raekwon McMillan (thumb) questionable
  • WR Jakobi Meyers (knee) questionable
  • TE Jonnu Smith (ankle) questionable
  • LB Josh Uche (hamstring) out

Browns

  • DE Jadeveon Clowney (ankle, knee, elbow) out
  • CB Denzel Ward Jr. (concussion) out

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Patriots at Browns picks and predictions

Prediction

Browns 26, Patriots 20

Moneyline

The BROWNS (-140) are a decent play on the moneyline if you don’t feel like fiddling around with the spread.

This is an interesting game as Cleveland should be able to pound the ball on the ground against a New England rush defense that ranks in the bottom third of the league. The Browns are the top running team in the NFL, and that will be the difference here.

Against the spread

CLEVELAND -2.5 (-117) comes with a little risk as all but one of the Browns’ games have been decided by one score. Cleveland’s 29-17 Thursday night Week 3 win against the Pittsburgh Steelers would have been if not for “pitchy woo-woo” at the end that resulted in a meaningless TD with no time left on the clock.

Still, the Patriots are vulnerable to the run, and that’s the Browns’ strength. Plus, there are just too many injuries at key spots for the Pats.

Over/Under

OVER 43.5 (-108) is the lean here, although it might not cross the finish line until late in the fourth quarter. So, go lightly.

Again, the Browns will look to run, run and run some more. Usually that doesn’t lend itself to Over results as running games help take time off the clock for Unders to cash.

But despite a pass attack that ranks just 24th in the NFL, Cleveland ranks 6th in the league at 26.6 points per game, and its defense hasn’t stopped anybody.

More NFL Week 6 odds, picks and predictions

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