Los Angeles Dodgers at San Diego Padres odds, picks and predictions

Analyzing Wednesday’s Los Angeles Dodgers at San Diego Padres odds and lines, with MLB expert picks, predictions and best bets.

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The Los Angeles Dodgers (63-45) and San Diego Padres (58-51) wrap up a 2-game set at Petco Park Wednesday. First pitch is scheduled for 8:40 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Dodgers vs. Padres odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 6-3

The Padres won 6-5 in 10 innings as +118 underdogs in the opener Tuesday as the Over (7) cashed. PH Donovan Solano hit a walk-off single in the 10th inning for San Diego, which came all the way back from an early 5-0 deficit.

The NL West-leading Dodgers had a 93% win probability, according to ESPN Analytics, heading into the top of the 9th inning with a 5-3 lead. L.A. has lost 4 of its last 6 after going on a 5-game win streak July 19-23 out of the All-Star break.

Dodgers at Padres projected starters

LHP Clayton Kershaw vs. RHP Dylan Cease

Kershaw (0-0, 4.50 ERA) makes his 2nd start. He allowed 2 ER on 6 hits and 2 walks with 6 K’s in 4 IP in his season debut, a 6-4 home victory over the San Francisco Giants Thursday.

  • Was activated off 60-day IL Thursday after having offseason shoulder surgery
  • 2023 stats: 13-5, 2.46 ERA (131 2/3 IP, 36 ER), 1.06 WHIP, 9.4 K/9 in 24 starts
  • Career vs. Padres (regular season): 23-10, 2.12 ERA (296 2/3 IP, 70 ER), 0.99 WHIP, 9.6 K/9 in 46 starts, including 0-1 with 7.71 ERA (4 2/3 IP, 4 ER) in 1 start last year

Cease (10-8, 3.50 ERA) makes his 23rd start. He has a 0.99 WHIP, 2.7 BB/9 and 11.5 K/9 in 131 IP.

  • Last start: Win, 9 IP, 0 ER, 0 H, 3 BB, 9 K in 2nd no-hitter in Padres history, a 3-0 victory at Washington Nationals Thursday
  • 2024 home stats: 4-5, 3.32 ERA (59 2/3 IP, 22 ER), 1.02 WHIP, 12.2 K/9 in 10 starts
  • Career vs. Dodgers: 0-1, 1.80 ERA (10 IP, 2 ER), 1.60 WHIP, 16.2 K/9 in 2 starts, including 0-0 with 3.38 ERA (5 1/3 IP, 2 ER) in 1 start last season

Who’s going yard? Here’s a breakdown of today’s best home run props with our top picks. Include the BetMGM bonus code SBWIRE to score a $1,500 first-bet offer.

Dodgers at Padres odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 10:44 a.m. ET.

  • Moneyline (ML): Dodgers +115 (bet $100 to win $115) | Padres -135 (bet $135 to win $100)
  • Run line (RL)/Against the spread (ATS): Dodgers +1.5 (-200) | Padres -1.5 (+165)
  • Over/Under (O/U): 7 (O: -110 | U: -110)

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Dodgers at Padres picks and predictions

Prediction

Dodgers 5, Padres 4

Moneyline

The DODGERS (+115) don’t seem like an attractive team to back right now, especially after Kershaw’s mediocre season debut against the Giants Thursday. However, Cease may be due for a huge letdown after throwing a no-hitter at Washington in his last start.

L.A. is tied with the New York Yankees for 1st in MLB with a .334 on-base percentage, much better than the last 3 teams Cease has faced in the Nationals (16th), Cleveland Guardians (15th) and Atlanta Braves (24th).

While Cease’s stretch of 3 straight games allowing 0 ER has been impressive, he’ll be facing a much more dangerous batting order in the Dodgers, who will be extra focused after blowing a 5-run lead in the opener.

BET DODGERS (+115).

Run line/Against the spread

L.A. +1.5 (-200) should hit, but it’s hard to stay profitable in MLB betting into lines with this much vig.

PASS. Bet the ML and/or total instead.

Over/Under

I’m going against the market’s love for Cease in this spot. Seven is a key number in MLB totals, and I can’t bet the Under at this number when Cease is in a potential letdown spot after throwing a no-hitter.

Kershaw also allowed 2 ER in 4 IP in his season debut, and the jury’s still out on whether the 36-year-old can return to form after having offseason shoulder surgery.

BET OVER 7 (-110).

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