Las Vegas Raiders at Buffalo Bills odds, picks and predictions

Analyzing Sunday’s Las Vegas Raiders at Buffalo Bills Team odds and lines, with expert NFL picks and predictions.

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The Las Vegas Raiders (1-0) visit the Buffalo Bills (0-1) Sunday in Week 2 NFL action. Kickoff at Highmark Stadium is at 1 p.m. ET (CBS). Below, we analyze BetMGM Sportsbook’s lines around the Raiders vs. Bills odds, and make our expert NFL picks and predictions.

Las Vegas surprised almost everyone with a 17-16 road victory over the Denver Broncos in Week 1. New QB Jimmy Garoppolo managed the game well throwing for 200 yards and 2 touchdowns and found a great connection with fellow new Raider WR Jakobi Meyers who caught 9 of 10 targets for 81 yards and 2 touchdowns. However, Meyers suffered a concussion late in the game and is out for Week 2.

The Raiders are likely hoping to get more from RB Josh Jacobs who led the league last season in rushing yards but was held to 48 yards on 19 carries in Week 1.

All eyes will be on the Bills to see if they can avoid a 0-2 start for the first time since 2018 after they were stunned 22-16 in overtime by the New York Jets in Week 1. QB Josh Allen threw 3 interceptions, was sacked 5 times and lost a fumble in the loss, although he did find top WR Stefon Diggs 10 times for 102 yards and a touchdown. Diggs was the only Buffalo receiver to have more than 32 yards in the game.

The last time these teams met was in Oct. 2020 in Las Vegas when Buffalo recorded a 30-23 victory as a 3-point favorite. The Raiders are 4-2 against the spread (ATS) in their last 6 against the Bills but have lost 2 in a row against the number in the series.

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Raiders at Bills odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 9:09 a.m. ET.

  • Moneyline (ML): Raiders +310 (bet $100 to win $310) | Bills -400 (bet $400 to win $100)
  • Against the spread (ATS): Raiders +8.5 (-110) | Bills -8.5 (-110)
  • Over/Under (O/U): 47 (O: -110 | U: -110)

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Raiders at Bills key injuries

Raiders

  • DE Chandler Jones (persronal) out
  • WR Jakobi Meyers (concussion) out

Bills

  • None

Raiders at Bills picks and predictions

Prediction

Bills 27, Raiders 23

Moneyline

PASS.

No win is guaranteed when it comes to the Bills after we saw them blow last week’s game against the Jets and there is no way I’m going to bet this Buffalo team -310 against a surprising Raiders squad even playing in the friendly confines of Highmark Stadium. Even if the Bills dominated in Week 1, I’d never put down 3 units to win 1, it’s just a bad bet.

Against the spread

BET RAIDERS +8.5 (-110).

I really like the Raiders getting points in this one. Las Vegas really impressed me on the road in Denver in Week 1 as QB Jimmy Garoppolo did exactly what he needed to do to get the job done and their defense kept Sean Payton’s new-look Broncos’ offense in check.

QB Josh Allen needs to play better and I’m not convinced he’ll be able to do that in just one week’s time. He has not been right since former offensive coordinator Brian Daboll left for the Giants’ head coaching job. While the offense is basically the same, the coaching is different under Ken Dorsey.

Over/Under

BET OVER 47 (-110).

Despite both of these teams going Under their game total in each of their last 2 games, I feel like this game could be a sneaky shootout.

The Raiders and Bills are 5-0-1 to the Over in their last 6 meetings dating back to Sept. 2008.

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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