The Lady Vols (1-0) will host East Tennessee State (1-0) Tuesday at Thompson-Boling Arena.
Tipoff is slated for 7:02 p.m. EST. SEC Network+ will stream the in-state matchup.
Tennessee opened the 2020-21 season with a 87-47 win against Western Kentucky. East Tennessee State defeated Longwood, 62-56, in its season opener.
Tennessee leads the all-time series with East Tennessee State, 23-2-1.
The last meeting between the two schools came on Nov. 5, 2019. Tennessee was victorious, 72-68, opening the Kellie Harper head coaching era in front of a crowd of 5,881 at Freedom Hall in Johnson City, Tennessee.
The Lady Vols are 249-61-1 all-time versus four- year college teams from the Volunteer State.
Tennessee was 4-0 against in-state teams last season, defeating East Tennessee State, Tennessee State and Vanderbilt at home and the Commodores on the road.