Complete 2021 Regular Season Schedule
| Week | Opponent | Date/Time (CT) | Network |
| 1 | @ Tampa Bay Buccaneers | THUR 9/9 7:20p | NBC |
| 2 | @ Los Angeles Chargers | 9/19 3:25p | CBS |
| 3 | vs Philadelphia Eagles | MON 9/27 7:15p | ESPN |
| 4 | vs Carolina Panthers | 10/3 Noon | FOX |
| 5 | vs New York Giants | 10/10 3:25p | FOX |
| 6 | @ New England Patriots | 10/17 3:25p | CBS |
| 7 | BYE | BYE | BYE |
| 8 | @ Minnesota Vikings | 10/31 7:20p | NBC |
| 9 | vs Denver Broncos | 11/7 Noon | FOX |
| 10 | vs Atlanta Falcons | 11/14 Noon | FOX |
| 11 | @ Kansas City Chiefs | 11/21 3:25p | FOX |
| 12 | vs Las Vegas Raiders | THUR 11/25 3:30p | FOX |
| 13 | @ New Orleans Saints | THUR 12/2 7:20p | FOX |
| 14 | @ Washington Football Team | 12/12 Noon | FOX |
| 15 | @ New York Giants | 12/19 Noon | FOX |
| 16 | vs Washington Football Team | 12/26 7:20p | NBC |
| 17 | vs Arizona Cardinals | 1/2 Noon | FOX |
| 18 | @ Philadelphia Eagles | TBD | FOX |