Houston Astros at San Francisco Giants odds, picks and predictions

Analyzing Wednesday’s Houston Astros at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Houston Astros (31-37) and San Francisco Giants (33-35) meet Wednesday for the finale of a 3-game series. First pitch from Oracle Park is set for 3:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Astros vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Tied 1-1

Houston beat San Francisco 3-1 in the 2nd game of the series Tuesday while cashing as a +103 road underdog. The Astros broke the 1-1 tie in the top of the 5th innings thanks to an error by 3B Matt Chapman. Tuesday’s win snapped a 2-game losing skid for Houston.

RHP Jordan Hicks picked up the loss for San Francisco, allowing 3 ER on 5 hits and 1 walk with 5 K’s in 4 2/3 innings. The Giants have lost 2 of their last 3 outings.

Astros at Giants projected starters

LHP Framber Valdez vs. RHP Logan Webb

Valdez (5-3, 3.53 ERA) makes his 11th start. He has a 1.15 WHIP, 2.5 BB/9 and 7.1 K/9 in 63 2/3 innings.

  • Last start: Win, 9 IP, 1 ER, 4 H, 1 BB, 8 K in 7-1 victory at Los Angeles Angels Friday
  • Career vs. San Francisco: 1-1, 3.27 ERA (11 IP, 4 ER), 1.27 WHIP, 11.5 K/9 in 2 starts

Webb (5-5, 2.92 ERA) makes his 15th start. He has a 1.20 WHIP, 2.1 BB/9 and 7.6 K/9 in 86 1/3 innings.

  • Last start: Win, 7 IP, 2 ER, 5 H, 0 BB, 6 K in 5-2 victory at Texas Rangers Friday
  • Career vs. Houston: 2-1, 3.18 ERA (17 IP, 6 ER), 1.18 WHIP, 5.8 K/9 in 3 starts

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Astros at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:30 a.m. ET.

  • Moneyline (ML): Astros -105 (bet $105 to win $100) | Giants -115 (bet $115 to win $100)
  • Run line (RL)/Against the spread (ATS): Astros -1.5 (+165) | Giants +1.5 (-200)
  • Over/Under (O/U): 7.5 (O: +100 | U: -120)

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Astros at Giants picks and predictions

Prediction

Giants 3, Astros 1

Moneyline

LEAN GIANTS (-115).

San Francisco is 3-1 in the last 4 meetings overall and 3-1 in the last 4 meetings at Oracle Park.

This is only a lean because the Astros enter as the slightly hotter team, going 6-4 in their last 10 games overall and 3-2 in their last 5 on the road, while the Giants are only 4-6 in their last 10 and 1-4 in their last 5 at home.

Run line/Against the spread

PASS.

I like the Giants to cover here as +1.5 (-200) underdogs, but the line is simply not worth the risk of betting on at this price. Bet on the moneyline and/or total instead.

Over/Under

BET UNDER 7.5 (-120).

The Under has hit in 4 of Houston’s last 5 road games and is 7-3 in its last 10 overall. For San Francisco, the Under is 4-1 in its last 5 outings. The Under has also hit in each of the last 4 Houston-San Francisco matchups overall and is 3-0 in the last 3 meetings in the Bay Area.

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