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The Houston Astros (30-36) and San Francisco Giants (32-34) begin a 3-game interleague series at Oracle Park on Monday. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze FanDuel Sportsbook’s lines around the Astros vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: First meeting; Giants won 2-1 in 2023
The Astros took 2 of 3 from the Los Angeles Angels over the weekend, winning a series for the 2nd straight time since June 3. Houston won the previous interleague series against the St. Louis Cardinals Monday through Wednesday, too.
On the road, Houston has struggled, going just 8-13 in the past 21 games not including a pair of neutral-site games in Mexico City on April 27-28.
The Under is 3-1 in the past 4 games for Houston, while going 12-3 in the past 15 outings. On the road, the total has gone low at a 8-1 clip in the past 9 tries.
For the Giants, they suffered a 7-2 loss in the interleague series finale at the Texas Rangers on Sunday, but San Francisco won the 1st 2 battles in that series. The Giants are just 3-7 in the past 10 games, however, and they’ve dropped the past 4 games at home, too.
Astros at Giants projected starters
RHP Spencer Arrighetti vs. LHP Kyle Harrison
Arrighetti (3-5, 5.79 ERA) makes his 11th start. He has a 1.67 WHIP, 5.0 BB/9 and 10.6 K/9 in 46 2/3 IP.
- Last start: No-decision, 3 IP, 1 ER, 3 H, 3 BB, 4 K in an 8-5 home win vs. St. Louis Cardinals last Tuesday
- 2024 road splits: 1-4, 7.54 ERA (22 2/3 IP, 19 ER), 1.90 WHIP, .309 opponents’ batting average (OBA), 4 HR, 14 BB, 29 K in 5 starts
Harrison (4-3, 4.18 ERA) makes his 14th start. He has a 1.39 WHIP, 3.0 BB/9 and 6.0 K/9 in 71 IP.
- Last start: Loss, 6 IP, 4 R (3 ER), 8 H, 0 BB, 5 K in 8-5 road loss vs. Arizona Diamondbacks last Tuesday
- 2024 home splits: 1-1, 4.65 ERA (31 IP, 16 ER), 1.45 WHIP, .286 OBA, 3 HR, 9 BB, 34 K in 6 starts
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Astros at Giants odds
Provided by FanDuel Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:26 a.m. ET.
- Moneyline (ML): Astros -118 (bet $118 to win $100) | Giants +100 (bet $100 to win $100)
- Run line (RL)/Against the spread (ATS): Astros -1.5 (+146) | Giants +1.5 (-176)
- Over/Under (O/U): 8 (O: -122 | U: +100)
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Astros at Giants picks and predictions
Prediction
Giants 7, Astros 5
Moneyline
The GIANTS (+100) are a decent play at even-money in this interleague series opener at home.
Arrighetti has been awful for the Astros (-118), particularly on the road, and it won’t help that there is a jetstream blowing out to the left-center field power alley.
The Astros just can’t seem to develop any momentum or play with any consistency.
Run line/Against the spread
If you’re a little more on the conservative side, and just can’t play San Francisco straight up, backing GIANTS +1.5 (-176) isn’t priced out of line for a little bit of insurance.
The Giants have lost 4 in a row at home, so they’re anything but a slam-dunk play. Of course, Astros -1.5 (+146) are 6 games under .500 this season, and Arrighetti has an ERA north of 7 on the road.
Over/Under
OVER 8 (-122) is the best play on the board in this interleague series opener.
The wind will be blowing out from home plate to the left-center field power alley at an 8-11 mph clip.
While the Under has dominated for the Astros lately, the Over is 5-2 in Arrighetti’s past 7 starts.
For the Giants, the Over is 6-3 in the past 9 outings, and 9-4 in the previous 13 home contests. The total has gone high in 4 of the past 5 starts by the southpaw Harrison, too.
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