Sunday Night Football in Week 3 features the Green Bay Packers (1-1) visiting the San Francisco 49ers (2-0). Kickoff is 8:20 p.m. ET at Levi’s Stadium. Below, we look at the Packers at 49ers odds and lines, and make our best NFL picks, predictions and bets.
Green Bay started the year by getting throttled 38-3 on the road against the New Orleans Saints. Packers QB Aaron Rodgers threw 2 interceptions and was held without a touchdown pass and just 133 passing yards. The Packers gained only 229 yards. They bounced back in Week 2 on Monday Night Football with a 35-17 win over the Detroit Lions. Rodgers had 4 touchdown passes in the win.
The 49ers are one of three undefeated teams in the NFC West. They opened the season with a 41-33 win in Week 1 over the Detroit Lions. They were up 41-17 with under 10 minutes left before the Lions scored a couple of garbage-time touchdowns. They then beat the Philadelphia Eagles 17-11 in Week 2.
Packers at 49ers odds, spread and lines
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 9:09 a.m. ET.
- Money line: Packers +135 (bet $100 to win $135) | 49ers -170 (bet $170 to win $100)
- Against the spread (ATS): Packers +3.5 (-122) | 49ers -3.5 (-102)
- Over/Under (O/U): 50.5 (O: -115 | U: -105)
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Packers at 49ers key injuries
Packers
- LT Elgton Jenkins (ankle) out
49ers
- DE Arik Armstead (adductor) questionable
- DT Javon Kinlaw (knee) questionable
- RB Elijah Mitchell (shoulder) doubtful
- RB JaMycal Hasty (ankle) out
- CB Emmanuel Moseley (knee) questionable
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Packers at 49ers odds, lines, predictions and picks
Prediction
Packers 23, 49ers 20
Money line
This will be the fourth year in a row the Packers and 49ers face each other in the regular season and the third straight regular-season game between them in San Francisco. They split the previous two regular-season meetings at Levi’s Stadium.
It is tough to know whether either team is good offensively based on the first couple of weeks of the season. The 49ers piled on 41 points in Week 1 but struggled to move the ball in Week 2. The Packers scored 35 last week but managed only a field goal in their opener against the Saints.
The game becomes the measuring stick for both teams.
49ers QB Jimmy Garoppolo is nothing like Rodgers when he gets going, and Rodgers got going last week. The Niners are down their top two running backs to start the year, as Raheem Mostert is on injured reserve and Elijah Mitchell is doubtful.
Take the PACKERS (+135).
Against the spread
If the Packers more closely resemble how they played in Week 2 rather than Week 1 they are one of the best teams in the entire NFC. If the Niners do the same they will not have much of a chance to slow the Packers.
San Francisco will struggle to cover Green Bay’s receivers. The 49ers are already missing CB Jason Verrett for the season and with Moseley uncertain for the game.
Expecting an outright Packers win, I like them even more against the spread. Take the PACKERS +3.5 (-122).
Over/Under
Both teams are 1-1 O/U this year. However, both their big-scoring games came against the same opponent.
The Niners’ second game did not even crack 30 points, while the Packers’ season opener barely cracked the 40s.
Can the two teams together get into the 50s? I don’t think they will.
Take UNDER 50.5 (-105).
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