Green Bay Packers at San Francisco 49ers odds, picks and prediction

Previewing the Green Bay Packers at San Francisco 49ers Week 9 betting odds and lines, with NFL betting picks, tips and predictions.

The Green Bay Packers (5-2) visit the injury-ravaged San Francisco 49ers (4-4) at Levi’s Stadium for Thursday Night Football in Week 9. Kickoff will be at 8:20 p.m. ET. Below, we preview the Packers-49ers betting odds and lines and make our NFL picks and predictions.

Packers at 49ers betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Wednesday at 5:15 a.m. ET.

  • Money line: Packers -250 (bet $250, win $100) | 49ers +200 (bet $100, win $200)
  • Against the spread/ATS: Packers -5.5 (-110) | 49ers +5.5 (-110)
  • Over/Under: 49.5 (O: -110 | U: -110)

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Packers at 49ers game notes

  • The Packers have lost two of their last three games after a strong 4-0 start. They dropped a 28-22 decision to the NFC North rival Minnesota Vikings at Lambeau Field last week.
  • The 49ers took a 37-27 loss at the NFC West rival Seattle Seahawks in Week 8. The loss snapped a two-game win streak for the Niners.
  • 49ers QB Nick Mullens will make his third start of the season in Week 9. In all, he has completed 70.4% of 98 pass attempts for 852 yards and 4 touchdowns against 3 interceptions. QB Jimmy Garoppolo (ankle) was placed on the Reserve/Injured list.
  • The Packers backfield is a mess coming into this one. RB Aaron Jones (calf) is expected to miss a second straight game. RBs A.J. Dillon and Jamaal Williams were placed on the Reserve/COVID-19 list. Fifth-year pro Tyler Ervin should lead the group in Week 9; he has 76 yards from scrimmage on 10 touches this season.
  • Green Bay is 5-2 against the spread but covers by just 1.9 points per game. San Francisco is 4-4 ATS and covers by an average of 0.9 PPG.
  • The Packers are 4-3 against the Over/Under while the Niners are 4-4 against the projected point totals.

Packers at 49ers key injuries

Packers

  • RB Aaron Jones (calf) doubtful
  • LB Preston Smith (shoulder) questionable
  • WR Equanimeous St. Brown (knee) questionable
  • RB Jamaal Williams (COVID-19) out
  • RB A.J. Dillon (COVID-19) out

49ers

  • RB Tevin Coleman (knee) questionable
  • QB Jimmy Garoppolo (ankle) out/IR
  • TE George Kittle (foot) out/IR
  • WR Deebo Samuel (hamstring) out
  • Jaquiski Tartt (groin) questionable

Packers at 49ers: Odds, prediction, betting lines and picks

Prediction

Packers 27, 49ers 13

Money line (?)

The PACKERS (-250) and an angry QB Aaron Rodgers have an excellent bounce-back opportunity against the banged-up Niners. The Packers’ replacement-level backfield for TNF isn’t much of a detriment with the Niners down to their third-string (Jerick McKinnon) and fourth-string (JaMycal Hasty) running backs as well.

Lean on Rodgers and WR Davante Adams to outduel Mullens and The Replacements in the Bay Area.

Against the spread (?)

There’s much better value to be had by backing the PACKERS -5.5 (-110) to win by at least 6 points. So long as Rodgers is able to get Green Bay out to the early lead, there’s just no way for San Francisco to keep pace.

No team in the NFL has the current injury troubles of the reigning NFC champions.

Over/Under (?)

The corresponding pick here is the UNDER 49.5 (-110). The Packers will get an early lead and then be able to sit back and stifle Mullens and the Niners’ passing attack.

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