The Bills (3-2) were brought back down to the earth by a combination of jet lag and the Jaguars (3-2).
Out in London at Tottenham Hotspur Stadium, the Bills fell 25-20. After a slow start, the Bills got it together a bit more.
But it was too little, too late.
Miss any of the action? Want to check out how close to the Bills were to climbing back into it?
Find all the highlights of the action in the YouTube player below:
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