Florida State at Louisville odds, picks and predictions

Analyzing Friday’s Florida State at Louisville odds and lines, with college football expert picks, predictions and best bets.

The Florida State Seminoles (2-0, 0-0 ACC) and the Louisville Cardinals (1-1, 0-1 ACC) meet Friday at Cardinal Stadium. Kickoff is scheduled for 7:30 p.m. ET (ESPN). Below, we analyze Tipico Sportsbook‘s lines around the Florida State vs. Louisville school odds, and make our expert college football picks and predictions.

The Seminoles picked up a 47-7 win over Duquesne in the Week 0 opener, before beating LSU 24-23 on a neutral field in New Orleans Saturday. The Seminoles allowed the game-tying touchdown with zeroes on the clock to end regulation but blocked the extra point that was required to force overtime. Twitter exploded. The end.

The Cardinals were humbled 31-7 on the road against Syracuse in the ACC opener, so it is trying to avoid an 0-2 hole in conference play. Louisville did rebound with a strong defensive effort in a 20-14 road win at UCF last week.

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Florida State at Louisville odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Thursday at 6:24 a.m. ET.

  • Money line (ML): Florida State -145 (bet $145 to win $100) | Louisville +122 (bet $100 to win $122)
  • Against the spread (ATS): Florida State -2.5 (-117) | Louisville +2.5 (-103)
  • Over/Under (O/U): 56.5 (O: -115 | U: -105)

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Florida State at Louisville picks and predictions

Prediction

Louisville 31, Florida State 28

Money line

LOUISVILLE (+122) didn’t look very good in its first game, getting drilled by Syracuse in the opener. However, the defense was sound at UFC, and QB Malik Cunningham got back on track with a long scoring run to get the Cardinals over the hump. Cunningham has yet to toss a touchdown pass, but Louisville should be a lot more comfortable in its home opener.

Against the spread

LOUISVILLE +2.5 (-103) is a better play on the money line if you like them, but the option to get a couple of points of insurance is there. However, taking the Cardinals with less than 3 points is such a small amount. The Seminoles are just 1-5 ATS in the past 6 meetings in this series, and the home team is 5-2 ATS across the past 7 meetings.

Over/Under

The OVER 56.5 (-115) is the lean here. The Under is 2-0 for FSU so far and has cashed in 6 of its last 7 on the road, but the Over is 6-2 in the previous 8 meetings between these teams and 4-0 in the past 4 meetings in Louisville.

The Cardinals have managed just 13.5 PPG through 2 games, but this offense is certainly due. The Over is 11-5 in their last 16 home games, too, so expect a much better performance Friday — especially through the air.

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