First look: Seattle Seahawks at San Francisco 49ers odds and lines

Looking at Sunday’s Seattle Seahawks at San Francisco 49ers Week 2 NFL odds, lines and trends. Here’s what you need to know.

The Seattle Seahawks (1-0) and San Francisco 49ers (0-1) meet Sunday for a Week 2 contest at Levi’s Stadium. Kickoff is set for at 4:05 p.m. ET (FOX). Below, we look at Seahawks vs. 49ers odds from Tipico Sportsbook; check back for all our NFL picks and predictions.

Seattle is coming off a triumph over the Denver Broncos on Monday Night Football. The Seahawks scored all of their 17 points over the first 28 minutes of clock time and then held on for a 17-16 win. They won the game despite racking up just 253 total yards.

The 49ers lost a 19-10 game at the Chicago Bears Sunday. In rainy conditions, QB Trey Lance was held to a 13-for-28 mark in passing the football. The ‘Niners lost despite holding the Bears to just 204 total yards.

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Seahawks at 49ers odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Tuesday at 9:22 a.m. ET.

  • Money line: Seahawks +330 (bet $100 to win $330) | 49ers -420 (bet $420 to win $100)
  • Against the spread (ATS): Seahawks +8.5 (-112) | 49ers -8.5 (-108)
  • Over/Under (O/U): 42.5 (O: -108 | U: -112)

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2022 betting stats

  • ML: Seahawks 1-0 | 49ers 0-1
  • ATS: Seahawks 1-0 | 49ers 0-1
  • O/U: Seahawks 0-1 | 49ers 0-1

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Seahawks vs. 49ers head-to-head

Seattle beat San Francisco twice last season, both times in 1-score games. Six of the last 7 games between these NFC West foes have been decided by 8 points or fewer.

The all-time history between the Seahawks and 49ers includes 47 games; Seattle is 30-17 across those games.

Seattle earned ATS wins in both games last season and is 3-1 ATS in the last 4 series meetings. The Over is 3-1 across those same 4 games.

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