First look: Seattle Seahawks at San Francisco 49ers odds and lines

Looking at Sunday’s Seattle Seahawks at San Francisco 49ers Week 4 NFL odds, lines and trends. Here’s what you need to know.

In their first of two meetings this season, the Seattle Seahawks (1-2) will visit the San Francisco 49ers (2-1) on Sunday. Kickoff from Levi’s Stadium will be at 4:05 p.m. ET. Below, we look at the Seahawks vs. 49ers odds and lines; check back for our NFL picks and predictions.

The Seahawks have dropped two straight after beating the Indianapolis Colts in Week 1, losing to the Tennessee Titans in overtime and getting blown out by the Minnesota Vikings Sunday, 30-17.

It’s been a shaky start to the year for Seattle, which has allowed the most yards in the NFL through three weeks. QB Russell Wilson has been great once again, throwing seven touchdown passes and no interceptions so far.

The 49ers lost to the Green Bay Packers on a last-second field goal Monday night, falling 30-28 at home. QB Jimmy Garoppolo remains the starter over QB Trey Lance, with San Francisco ranking 16th in passing yards and 19th in total offense. The defense has been just average, too, ranking 16th in yards allowed and 17th in points allowed through three games.

Seahawks at 49ers odds, spread and line

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 11:11 a.m. ET.

  • Money line: Seahawks +125 (bet $100 to win $125) | 49ers -155 (bet $155 to win $100)
  • Against the spread (ATS): Seahawks +2.5, +105 (bet $100 to win $105) | 49ers -2.5, -130 (bet $130 to win $100)
  • Total (O/U): 51.5, Over -115 (bet $115 to win $100) | Under -105 (bet $105 to win $100)

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2021 betting stats:

  • ML: Seahawks 1-2 | 49ers 2-1
  • ATS: Seahawks 1-2 | 49ers 1-2
  • O/U: Seahawks 1-2 | 49ers 2-1

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Seahawks at 49ers head-to-head

The Seahawks have had the 49ers’ number in recent years and own the all-time series lead 28-17. Seattle swept San Francisco last season and has won 12 of the last 14 games against the 49ers dating back to 2014. They’ve each scored at least 21 points in each of the last five meetings.

The Seahawks beat San Francisco 26-23 in Week 17 last season, which came after they won the first meeting of the season, 37-27, back in November. The only losses by Seattle to the 49ers since 2014 came on Dec. 29, 2019 (26-21) and Dec. 16, 2018 (26-23 in OT).

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