First look: San Francisco 49ers at Seattle Seahawks odds and lines

Looking at Sunday’s San Francisco 49ers at Seattle Seahawks Week 13 NFL odds, lines and trends. Here’s what you need to know.

The San Francisco 49ers (6-5) and Seattle Seahawks (3-8) hook up Sunday in Week 13 at Lumen Field. Kickoff is slated for a 4:25 p.m. ET. Below, we look at the 49ers vs. Seahawks odds and lines; check back for our NFL picks and predictions.

The 49ers beat the visiting Minnesota Vikings 34-26 in Week 12. It was the third consecutive win and cover for San Francisco, which was a 4-point favorite against the Vikes. The 49ers finished with 208 rushing yards, led by RB Elijah Mitchell (133 yards, 1 TD) and WR Deebo Samuel (66 yards, 2 TDs), who unfortunately, exited in third quarter with a groin injury and is expected to miss one or two games. QB Jimmy Garoppolo added 230 passing yards with a touchdown and an interception.

The Seahawks lost 17-15 as 1.5-point favorites at the Washington Football Team Monday night. QB Russell Wilson (247 passing yards, 2 TDs) made it interesting – on his 33rd birthday – when he found WR Freddie Swain for a 32-yard touchdown pass with 15 seconds to go, but Wilson was picked off on the 2-point conversion attempt. It’s the first time he has lost three in a row as Seattle’s starting QB. The Seahawks, who scored just 28 points in the three losses, have pretty much dropped out of playoff contention with a 1-6 SU showing over the last seven games.

Also see: All Week 13 odds and lines

49ers at Seahawks odds, spread and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Tuesday at 7:20 a.m. ET.

  • Money line: 49ers -175 (bet $175 to win $100) | Seahawks +140 (bet $100 to win $140)
  • Against the spread (ATS): 49ers -3.5, +100 (bet $100 to win $100) | Seahawks +3.5, -120 (bet $120 to win $100)
  • Over/Under (O/U): 45.5, O: -110 (bet $110 to win $100) | U: -110 (bet $110 to win $100)

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2021 betting stats:

  • ML: 49ers 6-5 | Seahawks 3-8
  • ATS: 49ers 5-6 | Seahawks 5-6
  • O/U: 49ers 6-5 | Seahawks 1-10

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49ers at Seahawks head-to-head

The Seahawks lead the all-time series 29-17, including 1-0 in the postseason – a 23-17 road win in the 2013 NFC Championship Game.

Seattle has won the last three meetings, including a 28-21 road victory as a 2.5-point underdog in Week 4. The last time they faced off in Seattle, the Seahawks claimed a 37-27 win as 1-point favorites in Week 8 of last season.

Including the 2013 NFC title game, the Seahawks are 14-2 in the last 16 vs. the 49ers.

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