The San Francisco 49ers (1-0) and Philadephia Eagles (1-0) have a Week 2 meeting Sunday in Philadelphia. Kickoff from Lincoln Financial Field is set for 1 p.m. ET. Below, we look at the 49ers vs. Eagles odds and lines; check back for our NFL picks and predictions.
Also see: All Week 2 odds and lines
The 49ers opened their season with a commanding 41-33 victory at the Detroit Lions, but a 16-point quarter from the home side resulted in a backdoor over of the 9.5-point spread. QB Jimmy Garoppolo was 17-for-25 for 314 yards with 1 TD and rookie QB Trey Lance completed his only pass for a 5-yard TD.
WR Deebo Samuel led the way with 9 receptions on 12 targets for 189 yards and a score, while rookie RB Elijah Mitchell fronted the ground attack after starter Raheem Mostert was forced to exit the game with an injury. Mitchell racked up 104 yards on 19 carries and added a rushing TD. The game cleared the 46-point projected total in the third quarter.
The Eagles opened their season with a 32-6 victory as 3-point underdogs at the Atlanta Falcons. QB Jalen Hurts threw for 264 yards and 3 TD on 27-for-35 passing and added 62 rushing yards on 7 carries. First-round draft pick WR DeVonta Smith led the receiving corps with 71 yards on 6 receptions from 8 targets.
Philadelphia kept Atlanta in check by limiting QB Matt Ryan to 164 passing yards and starting RB Mike Davis to 49 yards on 15 carries as the game finished 11 points shy of the posted total of 49.
49ers at Eagles odds, spread and line
Odds provided by Tipico Sportsbook; access USA TODAY Sports’ betting odds for a full list. Lines last updated Monday at 5:30 p.m. ET.
- Money line: 49ers -200 (bet $200 to win $100) | Eagles +160 (bet $100 to win $160)
- Against the spread (ATS): 49ers -3.5, -115 (bet $115 to win $100) | Eagles +3.5, -107 (bet $107 to win $100)
- Total (O/U): 50.5, Over -105 (bet $105 to win $100) | Under -115 (bet $115 to win $100)
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2021 betting stats:
- ML: 49ers 1-0 | Eagles 1-0
- ATS: 49ers 0-1 | Eagles 1-0
- O/U: 49ers 1-0 | Eagles 0-1
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49ers at Eagles head-to-head
The 49ers and Eagles have met just once since 2017.
Philadelphia picked up a 25-20 victory as an 8.5-point road underdog in Week 4 last season while the total stayed 1 point Under the number.
However, there has been significant changes to both rosters since that game as Garoppolo was sidelined for the 49ers in last season’s meeting and then-Eagles QB Carson Wentz has left.
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