First look: Notre Dame at Syracuse odds and lines

Looking at Saturday’s Notre Dame at Syracuse college football odds, lines and trends. Here’s what you need to know.

The Notre Dame Fighting Irish (4-3) and Syracuse Orange (6-1) meet Saturday at JMA Wireless Dome in Syracuse, N.Y. Kickoff is scheduled for noon ET (ABC). Below, we look at Notre Dame vs. Syracuse odds from Tipico Sportsbook; check back for all our college football picks and predictions.

The Fighting Irish had little trouble with UNLV at home, posting a 44-21 win as the Over (45.5) cashed. Notre Dame (-25.5) failed to cover for the 2nd straight game, and 4th time in the last 6 games.

The Orange suffered their 1st loss of the season, falling 27-21 at Clemson in a heartbreaker. Syracuse led 21-10 heading to the final quarter before it was outscored 17-0 in the final 15 minutes.

Syracuse is No. 16 in the AFCA Coaches Poll powered by USA TODAY Sports.

Stream select live college football games and full replays: Get ESPN+

Notre Dame at Syracuse odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:52 a.m. ET.

  • Moneyline (ML): Off the board.
  • Against the spread (ATS): Notre Dame +2.5 (-108) | Syracuse -2.5 (-112)
  • Over/Under (O/U): 45.5 (O: -115 | U: -107)

2022 betting stats

  • ML: Notre Dame 4-3 | Syracuse 6-1
  • ATS: Notre Dame 3-4 | Syracuse 6-1
  • O/U: Notre Dame 2-5 | Syracuse 2-5

Claim your risk-free bet up to $350. Catch the excitement and start betting with Tipico Sportsbook! New customer offer in CO and NJ. 21+, see Tipico.com for Terms and Conditions. Bet now!

Notre Dame at Syracuse head-to-head

These schools have met 10 times on the gridiron, with the Irish holding a 7-3 all-time lead. Notre Dame has won the last 4 meetings, with the last win for Syracuse coming in 2008 in South Bend 24-23. The Irish won the most recent meeting, also at Notre Dame Stadium, 45-21 win in 2020.

Play our free daily Pick’em Challenge and win! Play now!

Want action on this game or any other NCAA football matchup? Bet legally online with a trusted partner: Tipico Sportsbook, SportsbookWire’s official sportsbook partner in CO and NJ. Bet now!

If you’re looking for more sports betting picks and tips, access all of our content at SportsbookWire.com and BetFTW, or try out our USA TODAY Parlay Calculator. Please gamble responsibly.

Follow Kevin J. Erickson on Twitter. Follow SportsbookWire on Twitter and like us on Facebook.

College sports coverage from USA TODAY Sports Media Group:

Alabama / Arkansas / Auburn / Clemson / Colorado / Florida / Georgia / Iowa / LSU / Michigan / Michigan State / Nebraska / North Carolina / Notre Dame / Ohio State / Oklahoma / Oregon / Penn State / Rutgers / Tennessee / Texas / Texas A&M / USC / Wisconsin / College Football News

[lawrence-newsletter]

[lawrence-auto-related count=3 category=1622]