The Notre Dame Fighting Irish (4-3) and Syracuse Orange (6-1) meet Saturday at JMA Wireless Dome in Syracuse, N.Y. Kickoff is scheduled for noon ET (ABC). Below, we look at Notre Dame vs. Syracuse odds from Tipico Sportsbook; check back for all our college football picks and predictions.
The Fighting Irish had little trouble with UNLV at home, posting a 44-21 win as the Over (45.5) cashed. Notre Dame (-25.5) failed to cover for the 2nd straight game, and 4th time in the last 6 games.
The Orange suffered their 1st loss of the season, falling 27-21 at Clemson in a heartbreaker. Syracuse led 21-10 heading to the final quarter before it was outscored 17-0 in the final 15 minutes.
Syracuse is No. 16 in the AFCA Coaches Poll powered by USA TODAY Sports.
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Notre Dame at Syracuse odds
Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:52 a.m. ET.
- Moneyline (ML): Off the board.
- Against the spread (ATS): Notre Dame +2.5 (-108) | Syracuse -2.5 (-112)
- Over/Under (O/U): 45.5 (O: -115 | U: -107)
2022 betting stats
- ML: Notre Dame 4-3 | Syracuse 6-1
- ATS: Notre Dame 3-4 | Syracuse 6-1
- O/U: Notre Dame 2-5 | Syracuse 2-5
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Notre Dame at Syracuse head-to-head
These schools have met 10 times on the gridiron, with the Irish holding a 7-3 all-time lead. Notre Dame has won the last 4 meetings, with the last win for Syracuse coming in 2008 in South Bend 24-23. The Irish won the most recent meeting, also at Notre Dame Stadium, 45-21 win in 2020.
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