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The New York Giants (1-1) and the San Francisco 49ers (2-0) meet on Thursday Night Football at Levi’s Stadium in Santa Clara, Calif. Kickoff is scheduled for 8:15 p.m. ET (Prime Video). Below, we look at Giants vs. 49ers odds from BetMGM Sportsbook. Also see: SportsbookWire’s NFL picks and predictions.
The Giants opened the season with a 40-0 egg-laying at home on Sunday Night Football against the Dallas Cowboys. In Week 2, it appeared history would repeat itself, as New York was down 20-0 at halftime against the Arizona Cardinals. However, the G-Men rallied for a 31-28 road win.
The victory came with a price, however, as RB Saquon Barkley suffered an ankle injury late in the game. X-rays were negative, but he’ll have an MRI to determine the severity. He could be a question mark with the quick turnaround. If so, RB Matt Breida might be in line to start against his original NFL club.
The 49ers went on the road in Week 1 and spanked the Pittsburgh Steelers 30-7 for the cover and Under. San Francisco then hit the road for a 30-23 victory against the Los Angeles Rams, failing to cover after LA coach Sean McVay elected to kick a field goal with :00 left in regulation, angering plenty. The Over cashed in the divisional battle, too.
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Giants at 49ers odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 4:56 a.m. ET.
- Moneyline (ML): Giants +350 (bet $100 to win $350) | 49ers -450 (bet $450 to win $100)
- Against the spread (ATS): Giants +10 (-110) | 49ers -10 (-110)
- Over/Under (O/U): 45 (O: -110 | U: -110)
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2023 betting stats
- ML: Giants 1-1 | 49ers 2-0
- ATS: Giants 0-2 | 49ers 1-1
- O/U: Giants 1-1 | 49ers 1-1
Giants at 49ers head-to-head
This is the 1st regular-season meeting since Sept. 27, 2020, in the Meadowlands, with the 49ers coming away with a 36-9 victory, covering a 3-point number as the Over (44) just came in.
The last time these teams met in the Bay Area, the G-Men shocked the Niners 27-23 on Nov. 12, 2018, as 3-point underdogs as the Over (45) cashed. The 49ers are 4-1 ATS in the past 5 meetings, while the Over has cashed in 4 straight in the series.
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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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