First look: Colorado at USC Trojans odds and lines

Looking at Friday’s Colorado Buffaloes at USC Trojans college football odds, lines and trends. Here’s what you need to know.

The Colorado Buffaloes (1-8, 1-5 Pac-12) and No. 7 USC Trojans (8-1, 6-1) clash in a Pac-12 battle under the lights Friday. Kickoff at the Los Angeles Coliseum in Los Angeles is scheduled for 9:30 p.m. ET (FS1). Below, we look at Colorado vs. USC from Tipico Sportsbook; check back for all our college football picks and predictions.

Colorado allowed 40-plus points for a 3rd straight game — and lost a 3rd straight in the process — when it fell (as a 31-point underdog) to Oregon 49-10 Saturday. For the season, the Buffaloes have allowed 40.2 points per game, ranking 14th in the Pac-12 and 130th in FBS.

The Trojans — ranked 9th in the Nov. 1 College Football Playoff rankings — snuck by Cal 41-35 Saturday. USC, a 21-point favorite, led 34-14 heading into the 4th quarter. USC has now been involved in 3 consecutive 1-score games (2 wins, 1 loss).

Rankings courtesy the AFCA Coaches Poll powered by USA TODAY Sports.

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Colorado at USC odds

Provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Monday at 10:19  a.m. ET.

  • Moneyline: Off the board
  • Against the spread (ATS): Colorado +34 (-110) | USC -34 (-110)
  • Over/Under (O/U): 64.5 (O: -108 | U: -112)

2022 betting stats

  • ML: Colorado 1-8 | USC 8-1
  • ATS: Colorado 2-7 | USC 5-4
  • O/U: Colorado 6-3 | USC 6-3

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Colorado vs. USC head-to-head

The teams first met in 1927 and have met 14 times since, and USC has never lost. The Trojans are 15-0 in the series, which includes a game last year (Oct. 2, 2021) in Boulder, when USC covered a 9.5-point spread in a 37-14 win.

The Over prevailed by a half-point in last year’s contest and is 3-1 across the last 4 series games.

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