Cleveland Guardians at Houston Astros odds, picks and predictions

Analyzing Monday’s Cleveland Guardians at Houston Astros odds and lines, with MLB expert picks and predictions.

The Cleveland Guardians (17-20) open a 3-game set with the Houston Astros (27-15) Monday at Minute Maid Park. First pitch is scheduled for 8:10 p.m. ET. Let’s analyze Tipico Sportsbook‘s lines around the Guardians vs. Astros odds with MLB picks and predictions.

The Guardians are 4-6 in the last 10 games, including 1-3 in the last 4. They lost 4-2 Sunday at home to the Detroit Tigers.

Houston won 3 of a 4-game set at home vs. the Texas Rangers entering Monday. The Astros are 6-4 in their last 10, including wins in their last 2.

The Astros beat the Guardians 6-1 in last year’s season series, outscoring Cleveland 37-21.

Guardians at Astros projected starters

RHP Triston McKenzie vs. RHP Luis Garcia

Cleveland hasn’t officially announced a starter, but McKenzie is projected to get the nod. McKenzie is 2-3 with a 2.97 ERA, 0.96 WHIP, 2.7 BB/9 and 8.4 K/9 in 36 1/3 IP over 6 starts and 1 relief appearance.

  • Last start: 3-1 road loss at the Minnesota Twins May 15 with 7 IP, 3 ER, 3 H, 2 HR, 2 BB and 4 K.
  • 2021 vs. the Astros: One start, a 9-3 loss at Houston July 20 with 4 IP, 5 ER, 8 H, 2 HR, 1 BB and 3 K.

Garcia is 3-2 with a 3.35 ERA, 1.06 WHIP, 2.9 BB/9 and 9.8 K/9 in 37 2/3 IP over 7 starts.

  • Last start: 5-1 road loss at the Boston Red Sox Wednesday with 4 IP, 3 ER (5 R), 5 H, 1 HR, 3 BB and 4 K.
  • 2021 vs. the Guardians: One start, a 9-3 home win July 20 with 6-scoreless IP with 3 H, 0 BB and 8 K.

Guardians at Astros odds and lines

Odds provided by Tipico Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:42 p.m. ET.

  • Money line (ML): Guardians +160 (bet $100 to win $160) | Astros -200 (bet $200 to win $100)
  • Run line (RL)/Against the spread (ATS): Guardians +1.5 (-130) | Astros -1.5 (+105)
  • Over/Under (O/U): 8.5 (O: -107 | U: -115)

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Guardians at Astros picks and predictions

Prediction

Astros 6, Guardians 2

Money line

RISK only 1 UNIT on the ASTROS (-200) instead of betting to win 1 unit because Houston’s ML is expensive. The Astros have a 3-phase edge over the Guardians: Starting and relief pitching and hitting.

Houston’s bullpen has the best ERA in baseball (2.64) and the lineup has the most wRC+ vs. right-handed pitching (122), according to FanGraphs. Cleveland’s lineup has impressive advanced hitting numbers against righties, but the lowest hard-hit rate in the MLB (25.6%).

The Astros are 12-3 as home favorites and the Guardians are 4-11 as road underdogs. Garcia has a 3.01 xFIP, 0.80 WHIP and 25.4 K-BB% at home this season, whereas McKenzie’s numbers slightly dip on the road.

The ASTROS (-200) are the right side, but I wouldn’t risk more than 1 UNIT because of the high price. However, this is my favorite wager in this game.

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Run line/Against the spread

PASS with a “heavy” lean toward the Astros -1.5 (+105) because of their aforementioned 3-phase edge and the Guardians are 6-9 RL as road underdogs.

However, 4 of the last 5 head-to-head meetings were decided by a single run, Houston is just 7-8 RL as a home favorite and 4 of Garcia’s 7 starts have been 1-run games.

Over/Under

Slight LEAN to the UNDER 8.5 (-115).

Houston is 2-5 O/U in Garcia’s 7 starts and 4-11 O/U as a home favorite. The Under has the heavier juice (-115), which suggests oddsmakers are steering bettors towards the Over 8.5 (-107).

Both of these lineups are productive against right-handed pitching, the weather forecast is predicting temperatures in the low-to-mid-80s and a light breeze blowing out to center field.

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