Cincinnati Reds at San Francisco Giants odds, picks and predictions

Analyzing Friday’s Cincinnati Reds at San Francisco Giants odds and lines, with MLB expert picks, predictions and best bets.

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The Cincinnati Reds (16-21) and San Francisco Giants (17-22) open a 3-game set at Oracle Park Friday. First pitch is scheduled for 10:15 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Reds vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting; Giants won 4-3 last season

The Reds have lost 8 straight and are coming off a 5-4 home loss vs. the Arizona Diamondbacks Thursday with the total (9) pushing. SS Elly De La Cruz had 2 hits and his 22nd and 23rd stolen bases for the Reds, who failed to cash as -141 favorites.

The Giants lost 9-1 as -125 favorites at the Colorado Rockies Thursday with the Over (9.5) hitting. San Francisco had a 1-0 lead heading into the bottom of the 4th before Colorado jumped on RHP Keaton Winn, who allowed 7 runs on 8 hits in 3 2/3 innings.

Reds at Giants projected starters

LHP Andrew Abbott vs. RHP Logan Webb

Abbott (1-4, 3.32 ERA) makes his 8th start. He has a 1.16 WHIP, 2.6 BB/9 and 8.3 K/9 in 38 innings.

  • Last start: Loss, 5 IP, 2 ER, 7 H, 0 BB, 8 K in 2-1 home defeat vs. Baltimore Orioles Saturday
  • 2024 road stats: 1-2, 3.42 ERA (23 2/3 IP, 9 ER), 0.93 WHIP in 4 starts
  • Career vs. Giants: 1-1, 2.38 ERA (11 1/3 IP, 3 ER), 0.97 WHIP in 2 starts

Webb (3-3, 3.50 ERA) makes his 9th start. He has a 1.38 WHIP, 2.3 BB/9 and 7.0 K/9 in 46 1/3 innings.

  • Last start: Loss, 4 IP, 4 ER (5 R), 7 H, 2 BB, 6 K in 5-4 setback at Philadelphia Phillies Sunday
  • 2024 home stats: 2-0, 0.82 ERA (22 IP, 2 ER), 0.91 WHIP in 3 starts
  • 2023 vs. Reds: 0-1, 2.77 ERA (13 IP, 4 ER), 0.85 WHIP in 2 starts
  • Career vs. Reds: 2-1, 1.38 ERA (26 IP, 4 ER), 0.85 WHIP in 4 starts and 1 relief appearance

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Reds at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 5:36 p.m. ET.

  • Moneyline (ML): Reds +120 (bet $100 to win $120) | Giants -145 (bet $145 to win $100)
  • Run line (RL)/Against the spread (ATS): Reds +1.5 (-185) | Giants -1.5 (+150)
  • Over/Under (O/U): 7 (O: -105 | U: -115)

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Reds at Giants picks and predictions

Prediction

Giants 4, Reds 2

Moneyline

The Giants (-145) should hand Cincinnati its 9th straight loss with Webb on the mound in San Francisco. However, with how well the Giants right-hander has pitched at home this season, the run line at plus money is the more attractive play.

PASS. Bet the run line and/or total instead.

Run line/Against the spread

Webb has pitched 15 scoreless innings over his last 2 starts at Oracle Park. The Reds’ .211 batting average ranks last in the majors. They will struggle to score runs in the 1st 7 innings, and it’s unlikely that the Giants will score fewer than 4 runs for a 2nd straight game.

BET GIANTS -1.5 (+150).

Over/Under

The Under is 4-1-1 in the Reds’ last 6 games, and they’ve scored 2 runs or fewer in 5 of their last 7. Webb has struggled on the road this season, but the Under is 3-0 when he starts at home.

BET UNDER 7 (-115).

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